Daum I, Braun C, Riesch G, Miltner W, Ackermann H, Schugens M M, Birbaumer N
Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany.
Neurosci Lett. 1995 Sep 8;197(2):137-40. doi: 10.1016/0304-3940(95)11916-k.
The present study investigated the processing of painful electrical stimuli in patients with unilateral frontal or parietal lobe damage and matched control subjects. Patients with frontal lesions showed increased pain thresholds when the stimuli were administered contralateral to the lesion. While the peak-to-peak amplitudes of the N150/P250 components of the somatosensory potentials increased linearly with stimulus intensity in the control subjects, the responses in the frontal group did not change significantly between stimulation at pain and tolerance threshold. There was no evidence for altered pain processing in patients with parietal lobe lesions. The findings of the present study support the hypothesis of an involvement of the frontal cortex in pain perception in humans.
本研究调查了单侧额叶或顶叶损伤患者以及相匹配的对照受试者对疼痛性电刺激的处理情况。额叶损伤患者在损伤对侧施加刺激时疼痛阈值升高。在对照受试者中，体感诱发电位的N150/P250成分的峰峰值幅度随刺激强度呈线性增加，而额叶组在疼痛阈值和耐受阈值刺激之间的反应没有显著变化。没有证据表明顶叶损伤患者的疼痛处理发生改变。本研究结果支持额叶皮质参与人类疼痛感知这一假说。
