Yamaguchi S, Knight R T
Department of Neurology, University of California, Davis.
Electroencephalogr Clin Neurophysiol. 1992 Mar-Apr;84(2):139-48. doi: 10.1016/0168-5597(92)90018-7.
Temporal-parietal junction lesions reduce the auditory and upper limb somatosensory P3 event-related potential (ERP) to target and novel stimuli. The current study examined the somatosensory P3 to target and novel stimuli delivered to the sole of the foot in patients with unilateral temporal-parietal lesions (n = 6). Age-matched controls (n = 10) generated a parietal maximal target P3 and a frontal-central maximal novelty P3 ERP to foot stimulation. Unilateral temporal-parietal lesions abolished target and novelty P3 responses over all scalp sites for stimuli delivered contralateral to the lesion. The P3 was also reduced to ipsilateral stimuli at electrodes over the lesioned hemisphere with partial P3 preservation observed at electrode sites over the non-lesioned hemisphere. These results parallel the findings for upper limb stimulation and support the critical role of temporal-parietal cortex in P3 generation.
颞顶叶交界处病变会降低对目标和新异刺激的听觉及上肢体感P3事件相关电位（ERP）。本研究检测了单侧颞顶叶病变患者（n = 6）对施加于足底的目标和新异刺激的体感P3。年龄匹配的对照组（n = 10）对足部刺激产生顶叶最大目标P3和额中央最大新异P3 ERP。对于病变对侧施加的刺激，单侧颞顶叶病变消除了所有头皮部位的目标和新异P3反应。在病变半球上方的电极处，P3对同侧刺激也降低，而在非病变半球上方的电极部位观察到部分P3保留。这些结果与上肢刺激的发现相似，并支持颞顶叶皮质在P3产生中的关键作用。
