Roky R, Obál F, Valatx J L, Bredow S, Fang J, Pagano L P, Krueger J M
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USA.
Sleep. 1995 Sep;18(7):536-42.
During the past few years data have accumulated suggesting the involvement of prolactin (PRL) in rapid eye movement sleep (REMS) regulation. Pituitary PRL secretion seems to be, at least in part, sleep-dependent. PRL is also found in the central nervous system. PRL-containing neurons in the hypothalamus project to various structures in the brain. Systemic injection of PRL promotes REMS in rats, cats and rabbits. Intracerebroventricular injection of PRL enhances REMS in rats. Stimulation of endogenous PRL secretion by vasoactive intestinal peptide (VIP) also promotes REMS. Immunoneutralization of blood-borne PRL slightly reduces REMS. Various observations (hypoprolactinemic and hyperprolactinemic rats) indicate that PRL may act on REMS via modulating the diurnal rhythms of REMS. It is likely that hypothalamic PRL is more important for sleep regulation than circulating PRL. Hypothalamic PRL is likely involved in the mediation of the REMS-promoting activity of VIP. We conclude that PRL has a role in REMS regulation.
在过去几年中，积累的数据表明催乳素（PRL）参与快速眼动睡眠（REMS）的调节。垂体PRL分泌似乎至少部分依赖于睡眠。PRL在中枢神经系统中也有发现。下丘脑含PRL的神经元投射到大脑中的各种结构。全身注射PRL可促进大鼠、猫和兔的快速眼动睡眠。脑室内注射PRL可增强大鼠的快速眼动睡眠。血管活性肠肽（VIP）刺激内源性PRL分泌也可促进快速眼动睡眠。对血源性PRL进行免疫中和可略微减少快速眼动睡眠。各种观察结果（低催乳素血症和高催乳素血症大鼠）表明，PRL可能通过调节快速眼动睡眠的昼夜节律来作用于快速眼动睡眠。下丘脑PRL对睡眠调节可能比循环中的PRL更重要。下丘脑PRL可能参与介导VIP促进快速眼动睡眠的活性。我们得出结论，PRL在快速眼动睡眠调节中起作用。
