Mourtazaev M S, Kemp B, Zwinderman A H, Kamphuisen H A
Department of Neurology and Clinical Neurophysiology, Leiden University Hospital, The Netherlands.
Sleep. 1995 Sep;18(7):557-64. doi: 10.1093/sleep/18.7.557.
Low-frequency EEG was analyzed quantitatively during 2 nights in 40 females and 34 males aged 26 to 101 years. Analyses were based on Rechtschaffen and Kales NREM sleep stages, on absolute low-frequency amplitude (i.e. power in the range of 0.2-2.0 Hz) and on low-frequency continuity. The latter parameter describes how much (0-100%) of the current slow-wave activity is continued in the near-future EEG. Such continuation can occur through closed loops in the underlying neuronal network and cells. These loops are slow, thus corresponding to slow-wave frequencies, and can consist of electrophysiological, chemical and/or other pathways. The continuity percentage then monitors the relative activity of these loops. It does not depend directly on absolute EEG amplitudes. All analyzed parameters, including amplitude-independent continuity, decreased substantially and significantly with increasing age. The amplitudes of low-frequency EEG in females were significantly and substantially (40%) larger than those in males. However, the amplitude-independent continuity percentage did not differ between the genders. These findings support the notion that gender-related anatomical differences have a general effect on EEG amplitude, including during slow-wave sleep. Aging, however, specifically affects the neurophysiological slow-wave-generating mechanism.
对年龄在26至101岁之间的40名女性和34名男性在两个晚上的低频脑电图进行了定量分析。分析基于 Rechtschaffen 和 Kales 的非快速眼动睡眠阶段、绝对低频振幅（即0.2 - 2.0赫兹范围内的功率）以及低频连续性。后一个参数描述了当前慢波活动在不久后的脑电图中持续的比例（0 - 100%）。这种持续可以通过潜在神经网络和细胞中的闭环发生。这些环速度缓慢，因此对应于慢波频率，并且可以由电生理、化学和/或其他途径组成。连续性百分比随后监测这些环的相对活动。它并不直接取决于脑电图的绝对振幅。所有分析参数，包括与振幅无关的连续性，都随着年龄的增长而显著大幅下降。女性低频脑电图的振幅显著且大幅（40%）高于男性。然而，与振幅无关的连续性百分比在性别之间没有差异。这些发现支持了这样一种观点，即与性别相关的解剖学差异对脑电图振幅有普遍影响，包括在慢波睡眠期间。然而，衰老特别影响神经生理慢波产生机制。
