Durnev A D, Oreshchenko A V, Kulakova A V, Beresten' N F
Vopr Med Khim. 1995 Sep-Oct;41(5):50-3.
The cytogenetic activity of food dyes was examined in the experiments on male C57B1/6 mice which were orally given during 5 days the following daily doses: Tartrasine (E102), 0.5 and 5.0 mg/kg; Indigo carmine (E132), 1.4 and 14 mg/kg; Canset yellow (E110), 0.17 and 1.7 mg/kg; Cochenillerot A (E124), 0.63 and 6.3mg/kg; Azorubin (E122), 1 and 10 mg/kg and Patentblau V (E131), 0.08 and 0.8 mg/kg. Five hundred metaphase slides each were analyzed in the control and experimental test series. The findings may conclude that the dyes tested within the above dose ranges do not induce any increase in the level of cells with chromosomal damages in the inbred animals.
在对雄性C57B1/6小鼠进行的实验中，检测了食用色素的细胞遗传学活性。这些小鼠连续5天口服以下每日剂量的色素：柠檬黄（E102），0.5和5.0毫克/千克；靛蓝胭脂红（E132），1.4和14毫克/千克；日落黄（E110），0.17和1.7毫克/千克；胭脂虫红A（E124），0.63和6.3毫克/千克；偶氮玉红（E122），1和10毫克/千克；专利蓝V（E131），0.08和0.8毫克/千克。在对照和实验测试系列中，分别分析了500张中期染色体玻片。研究结果表明，在上述剂量范围内测试的色素不会导致近交系动物中染色体受损细胞水平的任何增加。
