Hughes J R, Andy O J
Electroencephalogr Clin Neurophysiol. 1979 Apr;46(4):428-43. doi: 10.1016/0013-4694(79)90144-5.
Nine patients had an amygdalotomy for attempted relief of intractable seizures and, as an aid for localization, recordings were made from the amygdala and later computer analyzed. The background activity is 3-18 c/sec; in response to odorants sinusoidal bursts are seen, synchronous with inspiration at 12-24 c/sec, but mainly 40-70 c/sec. Each odorant is associated with a given group of frequency components. However, for many different odorants the number of these components is restricted and the hypothesis is presented that odor discrimination in man's amygdala is not determined by which components are present, but the patterning of the components according to their amplitude. Odorants within the same odor class produced similar patterns of response. Epileptiform activity was recorded in two different forms, one in response to odors, similar in frequency to the slower bursts, except for sharper configurations, at times progressing to clinical seizures and the second as an insertion discharge from an advancing electrode, similar in frequency to the faster bursts. These latter data suggest that the repertoire of a given neural system or structure may be limited to specific frequencies but the configuration or patterning of these frequencies define the different states of the structure.
9名患者接受了杏仁核切开术以尝试缓解难治性癫痫发作，并且为了辅助定位，对杏仁核进行了记录，随后进行了计算机分析。背景活动为3 - 18次/秒；对气味刺激的反应中，可见正弦波爆发，与12 - 24次/秒的吸气同步，但主要为40 - 70次/秒。每种气味都与一组特定的频率成分相关。然而，对于许多不同的气味，这些成分的数量是有限的，并且提出了这样的假设，即人类杏仁核中的气味辨别不是由存在哪些成分决定的，而是由这些成分根据其振幅的模式决定的。同一气味类别的气味产生相似的反应模式。癫痫样活动以两种不同形式记录，一种是对气味的反应，频率与较慢的爆发相似，只是形态更尖锐，有时会发展为临床癫痫发作，另一种是推进电极的插入放电，频率与较快的爆发相似。这些最新数据表明，给定神经系统或结构的全部功能可能限于特定频率，但这些频率的构型或模式定义了该结构的不同状态。
