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Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid.

作者信息

Motulsky A G

出版信息

Am J Hum Genet. 1996 Jan;58(1):17-20.

PMID:8554053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1914958/
Abstract
摘要

相似文献

1
Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid.营养生态遗传学：同型半胱氨酸相关的动脉硬化性血管疾病、神经管缺陷与叶酸
Am J Hum Genet. 1996 Jan;58(1):17-20.
2
Primary prevention of neural-tube defects with folic acid.叶酸对神经管缺陷的一级预防
Eur J Obstet Gynecol Reprod Biol. 1994 Feb;53(2):147-52. doi: 10.1016/0028-2243(94)90225-9.
3
Similarities in the epidemiology of neural tube defects and coronary heart disease: is homocysteine the missing link?神经管缺陷与冠心病流行病学的相似之处：同型半胱氨酸是其中缺失的环节吗？
J Epidemiol Community Health. 1999 Dec;53(12):789-93. doi: 10.1136/jech.53.12.789.
4
The role of folic acid in deficiency states and prevention of disease.叶酸在缺乏状态及疾病预防中的作用。
J Fam Pract. 1997 Feb;44(2):138-44.
5
[Methylenetetrahydrofolate polymorphism, folic acid, homocysteine associated with neural tube defects].[亚甲基四氢叶酸多态性、叶酸、同型半胱氨酸与神经管缺陷的关系]
Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Oct;25(10):908-10.
6
Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome.
Am J Clin Nutr. 1999 Oct;70(4):429-30. doi: 10.1093/ajcn/70.4.429.
7
Folic acid to prevent neural tube defects: scientific advances and public health issues.
Curr Opin Obstet Gynecol. 1996 Dec;8(6):394-7.
8
Homocysteine and coronary artery disease.
Am J Crit Care. 1997 Jan;6(1):72-7.
9
C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects.亚甲基四氢叶酸还原酶基因的C677T多态性不影响患有神经管缺陷的土耳其儿童的叶酸、维生素B12和血清同型半胱氨酸水平。
Genet Mol Res. 2010 Jun 22;9(2):1197-203. doi: 10.4238/vol9-2gmr816.
10
Genetic variation in genes of folate metabolism and neural-tube defect risk.叶酸代谢基因的遗传变异与神经管缺陷风险
Proc Nutr Soc. 2006 May;65(2):204-15. doi: 10.1079/pns2006495.

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Fundamental origins of neural tube defects with a basis in genetics and nutrition.基于遗传学和营养的神经管缺陷的根本起源。
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Individualized folic acid supplementation based on MTHFR and MTRR gene polymorphisms reduces the risk of gestational diabetes mellitus in a Chinese population.基于亚甲基四氢叶酸还原酶（MTHFR）和蛋氨酸合成酶还原酶（MTRR）基因多态性的个体化叶酸补充可降低中国人群患妊娠期糖尿病的风险。
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Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects.抑制线粒体天冬氨酸-tRNA合成酶可减少高同型半胱氨酸血症相关的神经管和先天性心脏缺陷。
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Mol Genet Metab Rep. 2014 Nov 16;1:477-482. doi: 10.1016/j.ymgmr.2014.11.002. eCollection 2014.
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Quantitative assessment of maternal biomarkers related to one-carbon metabolism and neural tube defects.与一碳代谢和神经管缺陷相关的母体生物标志物的定量评估。
Sci Rep. 2015 Mar 2;5:8510. doi: 10.1038/srep08510.
6
Alcohol, DNA methylation, and cancer.酒精、DNA甲基化与癌症。
Alcohol Res. 2013;35(1):25-35.
7
Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.叶酸代谢途径中的遗传变异与神经管缺陷风险：已发表文献的荟萃分析。
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Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study.亚甲基四氢叶酸还原酶C677T基因多态性与结直肠癌风险：一项病例对照研究。
Oncol Lett. 2012 Aug;4(2):365-369. doi: 10.3892/ol.2012.740. Epub 2012 May 30.
9
Surrogate genetics and metabolic profiling for characterization of human disease alleles.替代遗传学和代谢组学分析用于鉴定人类疾病等位基因。
Genetics. 2012 Apr;190(4):1309-23. doi: 10.1534/genetics.111.137471. Epub 2012 Jan 20.
10
Suppression of homocysteine levels by vitamin B12 and folates: age and gender dependency in the Jackson Heart Study.维生素 B12 和叶酸对同型半胱氨酸水平的抑制：杰克逊心脏研究中的年龄和性别依赖性。
Am J Med Sci. 2012 Aug;344(2):110-5. doi: 10.1097/MAJ.0b013e31823782a5.

本文引用的文献

1
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.轻度高同型半胱氨酸血症的分子遗传学分析：亚甲基四氢叶酸还原酶基因中的常见突变是心血管疾病的遗传风险因素。
Am J Hum Genet. 1996 Jan;58(1):35-41.
2
Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.冠心病中甲基四氢叶酸还原酶的热不稳定缺陷
Circulation. 1993 Oct;88(4 Pt 1):1463-9. doi: 10.1161/01.cir.88.4.1463.
3
Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification.人类亚甲基四氢叶酸还原酶：cDNA的分离、定位及突变鉴定
Nat Genet. 1994 Jun;7(2):195-200. doi: 10.1038/ng0694-195.
4
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.热不稳定型5,10-亚甲基四氢叶酸还原酶作为轻度高同型半胱氨酸血症的一个病因
Am J Hum Genet. 1995 Jan;56(1):142-50.
5
Homocysteine metabolism in pregnancies complicated by neural-tube defects.神经管缺陷合并妊娠中的同型半胱氨酸代谢
Lancet. 1995 Jan 21;345(8943):149-51. doi: 10.1016/s0140-6736(95)90165-5.
6
Two novel missense mutations in the cystathionine beta-synthase gene in homocystinuric patients.同型胱氨酸尿症患者胱硫醚β-合酶基因中的两个新型错义突变。
Hum Genet. 1995 Aug;96(2):249-50. doi: 10.1007/BF00207394.
7
Hyperhomocysteinemia in premature arterial disease: examination of cystathionine beta-synthase alleles at the molecular level.早产动脉疾病中的高同型半胱氨酸血症：分子水平上胱硫醚β-合酶等位基因的检测
Hum Mol Genet. 1995 Apr;4(4):623-9. doi: 10.1093/hmg/4.4.623.
8
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida.突变的亚甲基四氢叶酸还原酶作为脊柱裂的一个风险因素。
Lancet. 1995 Oct 21;346(8982):1070-1. doi: 10.1016/s0140-6736(95)91743-8.
9
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.血浆同型半胱氨酸作为血管疾病危险因素的定量评估。增加叶酸摄入量的潜在益处。
JAMA. 1995 Oct 4;274(13):1049-57. doi: 10.1001/jama.1995.03530130055028.
10
A study of cardiovascular risk in heterozygotes for homocystinuria.同型胱氨酸尿症杂合子心血管风险的研究。
Am J Hum Genet. 1981 Nov;33(6):883-93.