Bold R J, Ishizuka J, Townsend C M
University of California at Davis-East Bay, Oakland, USA.
Ann Surg. 1996 Jan;223(1):4-11. doi: 10.1097/00000658-199601000-00002.
The authors discuss ongoing research to determine the mechanisms by which peptide hormones regulate growth of gastrointestinal cancer and ways in which this information might be used to develop noncytotoxic therapy.
Approximately 100,000 people die of cancer of the gastrointestinal (GI) tract each year. Surgery is curative only when the tumor is localized. Chemotherapy and radiotherapy have limited efficacy for locally advanced or widespread disease. Various peptide hormones regulate the growth of these tumors. As for breast and prostate cancer, the growth regulatory effect of these hormones is being studied as a potential mechanism of hormonal therapy.
Gut peptide hormones regulate the growth of GI malignancies through all-specific receptors and signal transduction pathways. Interruption or modification of these growth regulatory mechanisms may lead to specific noncytotoxic therapy. In combination with surgical extirpation, such hormonally based treatment may be curative of advanced GI cancer.
作者探讨了正在进行的研究，以确定肽类激素调节胃肠道癌生长的机制，以及如何利用这些信息开发非细胞毒性疗法。
每年约有10万人死于胃肠道（GI）癌。只有肿瘤局限时，手术才能治愈。化疗和放疗对局部晚期或广泛疾病的疗效有限。各种肽类激素调节这些肿瘤的生长。与乳腺癌和前列腺癌一样，这些激素的生长调节作用正在作为激素治疗的潜在机制进行研究。
肠道肽类激素通过特异性受体和信号转导途径调节胃肠道恶性肿瘤的生长。这些生长调节机制的中断或改变可能导致特异性非细胞毒性疗法。与手术切除相结合，这种基于激素的治疗可能治愈晚期胃肠道癌。
