Rabilloud T, Berthier R, Vinçon M, Ferbus D, Goubin G, Lawrence J J
Laboratoire de Biologie Moléculaire du Cycle Cellulaire, INSERM U309, Grenoble, France.
Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):699-705. doi: 10.1042/bj3120699.
The acidic peroxidoxin [also named thiol-specific antioxidant protein (TSA) or protector protein (PRP)], which plays a role in the response against oxidative stress, is one of the major proteins of red blood cells. In this work, we show that this protein is induced at early stages of erythroid differentiation prior to haemoglobin accumulation, which suggests that it may play a role at the erythroblast stage, where haemoglobinized, nucleated and genetically active cells are submitted to a maximally dangerous oxidative stress. The early accumulation of this protein has been demonstrated both on transformed cell systems and on normal differentiating human erythroid cells. This suggests that this protein may play an important role in the differentiation of the erythroid cells.
酸性过氧化物酶（也称为硫醇特异性抗氧化蛋白[TSA]或保护蛋白[PRP]）是红细胞的主要蛋白质之一，在应对氧化应激中发挥作用。在本研究中，我们发现该蛋白在血红蛋白积累之前的红系分化早期就被诱导产生，这表明它可能在成红细胞阶段发挥作用，在此阶段，已血红蛋白化、有核且具有遗传活性的细胞会面临最大程度的危险氧化应激。这种蛋白的早期积累已在转化细胞系统和正常分化的人类红系细胞中得到证实。这表明该蛋白可能在红系细胞的分化中起重要作用。
