Shau H, Kim A
Division of Surgical Oncology, UCLA Medical Center 90024-1782.
Biochem Biophys Res Commun. 1994 Feb 28;199(1):83-8. doi: 10.1006/bbrc.1994.1197.
Human natural killer enhancing factor genes (NKEF-A and B) share extensive homology with several genes from other organisms known to be induced by oxidative stress and to protect organisms and proteins from oxidative destruction. In this study, we have identified natural killer enhancing factor as an abundant protein in red blood cell cytosol. Highly purified natural killer enhancing factor blocks inactivation of enzymes by mixed metal-thiol oxidation. Thus, natural killer enhancing factor is a major antioxidant protecting red blood cells from oxidative injuries.
人类自然杀伤细胞增强因子基因（NKEF - A和B）与其他生物体的几个基因具有广泛的同源性，已知这些基因可被氧化应激诱导，并保护生物体和蛋白质免受氧化破坏。在本研究中，我们已确定自然杀伤细胞增强因子是红细胞胞质溶胶中的一种丰富蛋白质。高度纯化的自然杀伤细胞增强因子可通过混合金属 - 硫醇氧化来阻止酶的失活。因此，自然杀伤细胞增强因子是一种主要的抗氧化剂，可保护红细胞免受氧化损伤。
