Bunsey M D, Strupp B J
Department of Psychology, Cornell University, Ithaca, New York 14853-6301, USA.
Behav Neurosci. 1995 Oct;109(5):903-11. doi: 10.1037//0735-7044.109.5.903.
Rats were injected with the alpha 2-adrenergic antagonist idazoxan (IDZ) prior to testing on vigilance and distraction tasks. In the vigilance task, rats responded with nose pokes to brief visual cues presented at variable intervals following trial onset. The distraction task was similar except that irrelevant odor cues (distractors) were presented in the interval prior to light onset on some trials. IDZ injection had no effect on performance in the vigilance task. In the distraction task, however, the higher IDZ dose (1.0 mg/kg) modulated the propensity to make a premature response when the distractors were presented. Notably, the direction of the effect varied with the rats' baseline level of distractibility. This pattern of effects suggests that endogenous norepinephrine (NE) influences distractibility and/or selective attention.
在对大鼠进行警觉性和注意力分散任务测试之前，给它们注射α2 - 肾上腺素能拮抗剂咪唑克生（IDZ）。在警觉性任务中，大鼠在试验开始后以不同间隔呈现短暂视觉线索时，通过鼻戳做出反应。注意力分散任务与之相似，只是在某些试验中，在灯光亮起之前的间隔期间会呈现无关的气味线索（干扰物）。注射IDZ对警觉性任务的表现没有影响。然而，在注意力分散任务中，较高剂量的IDZ（1.0毫克/千克）在呈现干扰物时调节了做出过早反应的倾向。值得注意的是，这种效应的方向随大鼠注意力分散的基线水平而变化。这种效应模式表明内源性去甲肾上腺素（NE）会影响注意力分散和/或选择性注意。
