Haukipuro K, Risteli L, Kairaluoma M I, Risteli J
Department of Surgery, University of Oulu, Finland.
Surgery. 1990 Apr;107(4):381-8.
The concentration of the aminoterminal propeptide of type III procollagen (PIIINP) in serum as an indicator of tissue repair was studied in 71 surgical patients undergoing minor, moderate abdominal, major abdominal, or hip surgery. An increase in serum PIIINP concentrations took place within the first week, and its magnitude was related to the extent of the soft-tissue operations. After the hip replacement, the maximum PIIINP concentration was reached somewhat later. Very high levels of serum PIIINP were seen in three patients with serious wound infections. The serum PIIINP antigenicity consisted both before and after surgery of equal proportions of two forms, one corresponding to the propeptide as set free during synthesis of new collagen and the other being larger and probably derived from turnover of type III collagen fibers. The proportion of the latter form was accentuated in infection. In contrast, in the wound the form derived from synthesis of type III collagen predominated. These results suggest that the postoperative increase in serum PIIINP levels is partly the result of tissue repair and partly the result of whole-body turnover of type III collagen.
我们对71例接受小型手术、中型腹部手术、大型腹部手术或髋关节手术的外科患者进行了研究，以血清中III型前胶原氨基端前肽（PIIINP）浓度作为组织修复的指标。血清PIIINP浓度在第一周内升高，其升高幅度与软组织手术范围有关。髋关节置换术后，PIIINP浓度达到最大值的时间稍晚。3例严重伤口感染患者的血清PIIINP水平非常高。手术前后血清PIIINP抗原性均由两种比例相等的形式组成，一种对应于新胶原合成过程中释放的前肽，另一种较大，可能来源于III型胶原纤维的周转。后一种形式的比例在感染时增加。相反，在伤口中，来源于III型胶原合成的形式占主导地位。这些结果表明，术后血清PIIINP水平升高部分是组织修复的结果，部分是III型胶原全身周转的结果。
