Wernet D, Weiss B, Schmidt H, Northoff H
Department of Transfusion Medicine, University Hospital, Tübingen, Germany.
Br J Haematol. 1995 Nov;91(3):758-60. doi: 10.1111/j.1365-2141.1995.tb05382.x.
Nine years after allogenic bone marrow transplantation a strong anti-E was observed in a patient transplanted with bone marrow from his HLA-identical brother. This IgG anti-E, with a titre of 4000, was detected together with autoantibodies to red blood cells and platelets and was not induced by transfusion with E+ cells. The hypothesis is proposed that the anti-E represents either antigen-independent desuppression of the donor immune system sensitized at the time of bone marrow transplantation by E antigens in the recipient, or antigen-independent memory B-cell activation by Epstein-Barr virus infection.
在接受来自其 HLA 同型兄弟的骨髓移植九年后，一名患者体内观察到强效抗 -E。这种 IgG 抗 -E 效价为 4000，与针对红细胞和血小板的自身抗体同时被检测到，且不是由输注 E+细胞诱导产生的。提出的假设是，抗 -E 要么代表骨髓移植时受者体内 E 抗原致敏的供体免疫系统的抗原非依赖性去抑制，要么代表爱泼斯坦 - 巴尔病毒感染引起的抗原非依赖性记忆 B 细胞激活。
