同种异体骨髓移植后不久，受者针对血细胞抗原的抗体重新激活。

Reactivation of recipient antibody to blood cell antigens soon after allogeneic bone marrow transplantation.

作者信息

Wernet D, Schnaidt M, Northoff H

机构信息

Department of Transfusion Medicine, University Hospital, Tübingen, Germany.

出版信息

Vox Sang. 1996;71(4):212-5. doi: 10.1046/j.1423-0410.1996.7140212.x.

DOI:10.1046/j.1423-0410.1996.7140212.x

Abstract

Reactivation of recipient antibody to HLA and red blood cell antigens is described in 8 patients after allogeneic bone marrow transplantation. These IgG antibodies can be detected between day 10 and day 40 after transplantation and, in 1 patient, can be shown to be antigen-independent. We hypothesize that, induced by graft recognition of recipient antigens, antigen-independent activation of sensitized recipient B cells takes place leading to transient antibody production.

摘要

8例异基因骨髓移植患者出现了受者针对人类白细胞抗原（HLA）和红细胞抗原的抗体重新激活。这些IgG抗体可在移植后第10天至第40天之间检测到，在1例患者中，显示为抗原非依赖性。我们推测，受者抗原的移植物识别诱导了致敏受者B细胞的抗原非依赖性激活，导致短暂的抗体产生。

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