Taenaka Y, Masuzawa T, Tatsumi F, Anai H, Toda K, Akagi H, Nakatani T, Baba Y, Fya K, Wakisaka Y
Department of Artificial Organs, National Cardiovascular Center, Research Institute, Osaka, Japan.
ASAIO J. 1994 Jul-Sep;40(3):M314-8. doi: 10.1097/00002480-199407000-00015.
The authors have been developing an electrohydraulic (EH) artificial heart system for total implantation. This system consists of intrathoracic ventricles, an abdominally placed EH actuator, flexible silicone oil conduits, externally coupled transcutaneous energy transfer (TET) system, transcutaneous optical telemetry (TOT) system, internal battery, and internal control drive unit. Fitting was evaluated in chronic animal experiments as a pneumatic system in 11 goats weighing 55.2 +/- 4.2 kg and 3 calves of 52.3 +/- 1.2 kg. The longest survival time in calves was 111 days, and that in goats was 51 days. The assembled EH pump was implanted in two goats of 49 and 50 kg as an acute experiment, and 4.2-6.7 L/min of cardiac output was maintained. For the TET system, an internal coil 3 cm in diameter was implanted to make an arch covered by skin. Electric energy was transmitted from the external to the internal coil, and energy of about 20 W was carried through wires to an external load. The DC-to-DC efficiency of the system was 76-83% for 40 days. The TOT system with internal light emitting diodes and external photodiodes also was evaluated in a goat. Disalignment of up to 12 mm was tolerated. Although more improvement is necessary, most of the components showed characteristics desirable for a totally implantable system.
作者们一直在研发一种用于全植入的电动液压（EH）人工心脏系统。该系统由胸腔内心室、置于腹部的EH驱动器、柔性硅油导管、外部耦合的经皮能量传输（TET）系统、经皮光学遥测（TOT）系统、内部电池和内部控制驱动单元组成。在慢性动物实验中，对11只体重为55.2±4.2千克的山羊和3头体重为52.3±1.2千克的小牛进行了作为气动系统的适配评估。小牛的最长存活时间为111天，山羊的最长存活时间为51天。作为急性实验，将组装好的EH泵植入了两只体重分别为49千克和50千克的山羊体内，并维持了4.2 - 6.7升/分钟的心输出量。对于TET系统，植入了一个直径为3厘米的内部线圈，以形成一个被皮肤覆盖的弓形。电能从外部线圈传输到内部线圈，约20瓦的能量通过电线传输到外部负载。该系统的直流 - 直流效率在40天内为76 - 83%。带有内部发光二极管和外部光电二极管的TOT系统也在一只山羊身上进行了评估。最多可耐受12毫米的错位。尽管还需要更多改进，但大多数组件都显示出了全植入系统所需的特性。
