Masuzawa T, Taenaka Y, Tatsumi E, Ahn J M, Ohno T, Toda K, Miyazaki K, Wakisaka Y, Eya K, Baba Y, Nakatani T, Takano H, Uyama C, Koshiji K, Fukui Y, Takahashi K, Tsuchimoto K, Tsukahara K
Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
ASAIO J. 1996 Sep-Oct;42(5):M328-32. doi: 10.1097/00002480-199609000-00004.
The authors have been developing an electrohydraulic total artificial heart (TAH) system with a separately placed electrohydraulic energy converter to minimize anatomic constraints in the pericardial space. Improvements to the system and current status of the development are reported. The energy converter was miniaturized to improve implantability, and its thickness was reduced to 54 mm. System efficiency was increased by suppressing rush current at the time of motor reversal. Maximum cardiac output of the TAH system was 9 L/min, and maximum system efficiency increased to 10%. The blood pump system was implanted easily in the body of a 57 kg calf, and no significant temperature rise on the energy converter surface was observed. As the next step, main components were integrated into a total system. The transcutaneous energy transfer system could supply power to the TAH without a decline in pump performance, and the internal battery could support the system at 6.5 L/min of cardiac output for 1 hour without a decrease in cardiac output. The authors consider the TAH system with a separately placed energy converter the most promising approach to development of a TAH for smaller sized patients.
作者们一直在研发一种带有单独放置的电液能量转换器的全人工心脏（TAH）系统，以尽量减少心包腔内的解剖学限制。本文报告了该系统的改进情况及当前的研发状态。能量转换器已小型化以提高可植入性，其厚度减至54毫米。通过抑制电机反转时的冲击电流提高了系统效率。TAH系统的最大心输出量为9升/分钟，最大系统效率提高到了10%。血泵系统很容易植入一只57千克小牛的体内，且未观察到能量转换器表面有明显的温度升高。下一步，将主要部件集成到一个完整的系统中。经皮能量传输系统可为TAH供电而不降低泵的性能，内部电池可在6.5升/分钟的心输出量下支持系统运行1小时而不降低心输出量。作者们认为，带有单独放置的能量转换器的TAH系统是为体型较小的患者研发TAH的最具前景的方法。
