Tanjoh K, Shima A, Aida M, Tomita R, Kurosu Y
First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
Surg Today. 1995;25(9):774-7. doi: 10.1007/BF00311451.
To clarify how the kinetics of nitric oxide (NO) and active oxygen species are correlated with the occurrence of organ dysfunction in sepsis, the levels of monocyte-associated NO2, NO3, and active oxygen species were examined in severely septic patients with multiple organ dysfunction syndrome (group M; n = 5), and the results compared with those of postoperative patients who had undergone gastrointestinal surgery (group S; n = 5) and healthy volunteers (group C; n = 10). The production of NO2 and NO3 by monocytes was significantly higher in group M than in the other two groups, while the production of active oxygen species by monocytes was significantly higher in groups M and S, than in group C. A significant correlation between the production of NO2 and that of active oxygen species by monocytes was noted only in group M. These findings indicate that the simultaneous activation of NO and active oxygen species production by monocytes is a prerequisite for the onset of multiple organ dysfunction in severe sepsis.
为阐明一氧化氮（NO）和活性氧的动力学与脓毒症中器官功能障碍的发生如何相关，我们检测了患有多器官功能障碍综合征的严重脓毒症患者（M组；n = 5）单核细胞相关的NO2、NO3和活性氧水平，并将结果与接受胃肠手术的术后患者（S组；n = 5）及健康志愿者（C组；n = 10）的结果进行比较。M组单核细胞产生的NO2和NO3显著高于其他两组，而M组和S组单核细胞产生的活性氧显著高于C组。仅在M组中观察到单核细胞产生的NO2与活性氧之间存在显著相关性。这些发现表明，单核细胞同时激活NO和活性氧的产生是严重脓毒症中多器官功能障碍发生的先决条件。
