Hu H Y, Kato Y
Department of Medicine, Shimane Medical University, Izumo, Japan.
Endocr J. 1995 Aug;42(4):545-50. doi: 10.1507/endocrj.42.545.
Body composition was assessed by bioelectrical impedance analysis (BIA) in 11 female patients with Graves' disease and in 49 age-matched healthy Japanese women. Patients with Graves' disease were examined in the hyperthyroid state before treatment and in the stable euthyroid state after treatment with antihyroid drugs for 6 to 18 months. Body weight (BW), percent body fat (BF/BW), percent lean body mass (LBM/BW) and percent total body water (TBW/BW) were not statistically different between hyperthyroid Graves' patients and healthy subjects. Percent body cell mass (BCM/BW) was much lower in hyperthyroid Graves' patients than in healthy subjects (mean +/- SEM; 33.9 +/- 2.4% vs. 41.5 +/- 0.5%, P < 0.001). Percent ratio of extracellular water to total body water (ECW/TBW) was much greater in hyperthyroid Graves' patients than in healthy subjects (53.9 +/- 3.0% vs. 41.8 +/- 0.5%, P < 0.001). These abnormal ratios, BCM/BW and ECW/TBW, were normalized after treatment. Serum free T4 levels showed a positive correlation with ECW/TBW (r = 0.779) and a reverse correlation with BCM/BW (r = -0.760) in all of the patients with Graves' disease examined. These findings indicate that body composition is affected by thyroid hormones and that body composition in hyperthyroid Graves' disease is characterized by decreased BCM associated with increased ECW.
采用生物电阻抗分析（BIA）对11例格雷夫斯病女性患者和49例年龄匹配的健康日本女性进行身体成分评估。对格雷夫斯病患者在治疗前的甲状腺功能亢进状态以及使用抗甲状腺药物治疗6至18个月后的稳定甲状腺功能正常状态进行检查。甲状腺功能亢进的格雷夫斯病患者与健康受试者之间的体重（BW）、体脂百分比（BF/BW）、瘦体重百分比（LBM/BW）和总体水百分比（TBW/BW）无统计学差异。甲状腺功能亢进的格雷夫斯病患者的身体细胞质量百分比（BCM/BW）远低于健康受试者（平均值±标准误；33.9±2.4%对41.5±0.5%，P<0.001）。甲状腺功能亢进的格雷夫斯病患者的细胞外水与总体水的百分比（ECW/TBW）远高于健康受试者（53.9±3.0%对41.8±0.5%，P<0.001）。这些异常比值，即BCM/BW和ECW/TBW，在治疗后恢复正常。在所有接受检查的格雷夫斯病患者中，血清游离T4水平与ECW/TBW呈正相关（r = 0.779），与BCM/BW呈负相关（r = -0.760）。这些发现表明身体成分受甲状腺激素影响，甲状腺功能亢进的格雷夫斯病患者的身体成分特征是BCM减少且ECW增加。
