每日饥饿感与身体组成部分：II. 肥胖患者中的关系。

Daily hunger sensation and body compartments: II. Their relationships in obese patients.

作者信息

Cugini P, Salandri A, Cilli M, Ceccotti P, Di Marzo A, Rodio A, Fontana S, Pellegrino A M, De Francesco G P, Coda S, De Vito F, Colosi L, Petrangeli C M, Giovannini C

机构信息

Istituto di II Clinica Medica, University of Rome La Sapienza, Italy.

出版信息

Eat Weight Disord. 1999 Jun;4(2):81-8. doi: 10.1007/BF03339722.

DOI:10.1007/BF03339722

PMID:11234246

Abstract

Hunger sensation (HS) is a signal whose levels change during the 24-h day. The daily mean level of HS was correlated with the human body compartments, as investigated by bioelectrical impedance analysis, to detect the relationship between the orectic perception and both the free fat mass (FFM) and the fat body mass (FBM) in 22 clinically healthy subjects (CHS) (2 M, 20 W, BMI: 18.5-24.0 kg/m2) and 48 obese patients (OP) (4 M, 44 W, BMI: 25.2-54.7 kg/m2). In CHS, the daily mean level of HS correlated positively with the FFM and negatively with the FBM. These correlations were not present in OP. This lack of relationships between HS and the body compartments where energy is maximally consumed (i.e., the FFM) and maximally stored (i.e., the FBM) indicates that the orectic response to energy expenditure and the orectic inhibition to fat accumulation are feedback mechanisms which are impaired in obesity.

摘要

饥饿感（HS）是一种其水平在一天24小时内会发生变化的信号。通过生物电阻抗分析对22名临床健康受试者（CHS）（2名男性，20名女性，BMI：18.5 - 24.0 kg/m²）和48名肥胖患者（OP）（4名男性，44名女性，BMI：25.2 - 54.7 kg/m²）进行研究，以检测食欲感知与瘦体质量（FFM）和脂肪量（FBM）之间的关系，结果发现HS的每日平均水平与人体组成部分相关。在CHS中，HS的每日平均水平与FFM呈正相关，与FBM呈负相关。在OP中不存在这些相关性。HS与能量最大消耗部位（即FFM）和能量最大储存部位（即FBM）之间缺乏这种关系，表明对能量消耗的食欲反应和对脂肪堆积的食欲抑制是肥胖中受损的反馈机制。