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反刍动物立克次氏体主要免疫显性蛋白的大小变异

Size variation of the major immunodominant protein of Cowdria ruminantium.

作者信息

Barbet A F, Semu S M, Chigagure N, Kelly P J, Jongejan F, Mahan S M

机构信息

Department of Infectious Diseases, University of Florida, Gainesville 32611-0880, USA.

出版信息

Clin Diagn Lab Immunol. 1994 Nov;1(6):744-6. doi: 10.1128/cdli.1.6.744-746.1994.

DOI:10.1128/cdli.1.6.744-746.1994
PMID:8556531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368408/
Abstract

An immunodominant response is made to a polypeptide of approximately 32 kDa in animals infected with the rickettsial pathogen Cowdria ruminantium. We show here using cultured strains of the rickettsia from different geographical areas that the apparent size of this polypeptide varies with strain origin. Changes in the primary structure between strains should be considered in the design of vaccines and diagnostic tests based on this antigen.

摘要

在感染立克次氏体病原体反刍兽考德里氏体的动物中，会对一种约32 kDa的多肽产生免疫显性反应。我们在此利用来自不同地理区域的立克次氏体培养菌株表明，这种多肽的表观大小随菌株来源而变化。在基于该抗原设计疫苗和诊断测试时，应考虑菌株之间一级结构的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b770/368408/a5dac7edee4d/cdli00006-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b770/368408/5ea2c8c6d781/cdli00006-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b770/368408/8ae1226f9251/cdli00006-0145-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b770/368408/a5dac7edee4d/cdli00006-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b770/368408/5ea2c8c6d781/cdli00006-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b770/368408/8ae1226f9251/cdli00006-0145-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b770/368408/a5dac7edee4d/cdli00006-0146-a.jpg

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本文引用的文献

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Characterization of a heat-modifiable outer membrane protein of Haemophilus somnus.睡眠嗜血杆菌热可修饰外膜蛋白的特性分析
Infect Immun. 1993 May;61(5):1750-5. doi: 10.1128/iai.61.5.1750-1755.1993.
2
An immunoblotting diagnostic assay for heartwater based on the immunodominant 32-kilodalton protein of Cowdria ruminantium detects false positives in field sera.一种基于反刍动物考德里氏体免疫显性32千道尔顿蛋白的牛心水病免疫印迹诊断检测方法在现场血清中检测到假阳性。
J Clin Microbiol. 1993 Oct;31(10):2729-37. doi: 10.1128/jcm.31.10.2729-2737.1993.
3
The immunodominant 32-kilodalton protein of Cowdria ruminantium is conserved within the genus Ehrlichia.
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Exp Appl Acarol. 1998 Feb;22(2):111-22. doi: 10.1023/a:1006045710683.
4
Expression of Anaplasma marginale major surface protein 2 variants during persistent cyclic rickettsemia.边缘无形体主要表面蛋白2变异体在持续性循环立克次体血症期间的表达
Infect Immun. 1998 Mar;66(3):1200-7. doi: 10.1128/IAI.66.3.1200-1207.1998.
5
Sequence heterogeneity of the major antigenic protein 1 genes from Cowdria ruminantium isolates from different geographical areas.来自不同地理区域的反刍动物考德里氏体分离株主要抗原蛋白1基因的序列异质性。
Clin Diagn Lab Immunol. 1996 Jul;3(4):417-22. doi: 10.1128/cdli.3.4.417-422.1996.
6
Use of a specific immunogenic region on the Cowdria ruminantium MAP1 protein in a serological assay.在血清学检测中使用反刍动物考德里氏体MAP1蛋白上的特定免疫原性区域。
J Clin Microbiol. 1995 Sep;33(9):2405-10. doi: 10.1128/jcm.33.9.2405-2410.1995.
反刍动物考德里氏体的免疫显性32千道尔顿蛋白在埃立克体属内保守。
Rev Elev Med Vet Pays Trop. 1993;46(1-2):145-52.
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Infect Immun. 1988 Jun;56(6):1526-31. doi: 10.1128/iai.56.6.1526-1531.1988.
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Identification of an immunodominant antigenically conserved 32-kilodalton protein from Cowdria ruminantium.从反刍动物考德里氏体中鉴定出一种免疫显性的、抗原性保守的32千道尔顿蛋白。
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