Campistol J, Geli M, Llistosella E, Molins J, Llobet M
Consorci Sant Gregori, Girona.
Rev Neurol. 1995 Nov-Dec;23(124):1236-8.
We report a 18 years old female with Lennox-Gastaut syndrome under treatment with sodium valproate, carbamazepine and clonazepam. When seizures increased we stopped carbamazepine and introduced lamotrigine slowly. One month later the girl developed haemorrhagic erosions in mucoses and limbs with deterioration of her general state. Skin biopsy confirmed the diagnosis of erythema multiforme, the Stevens-Johnson's form. The immediate withdrawal of lamotrigine and treatment with antihystaminics and steroids was followed of a slowly favourable course with disappearance of symptomatology one month later. It's another case of Stevens-Johnson syndrome related to the introduction of lamotrigine in polytherapy.
我们报告一名18岁患有 Lennox-Gastaut 综合征的女性，正在接受丙戊酸钠、卡马西平和氯硝西泮治疗。当癫痫发作增加时，我们停用了卡马西平，并缓慢引入拉莫三嗪。一个月后，女孩出现黏膜和四肢出血性糜烂，全身状况恶化。皮肤活检确诊为多形红斑，即史蒂文斯-约翰逊综合征型。立即停用拉莫三嗪，并使用抗组胺药和类固醇进行治疗，随后病情缓慢好转，一个月后症状消失。这是另一例与在联合治疗中引入拉莫三嗪相关的史蒂文斯-约翰逊综合征病例。
