Sofi Fayaz A, Koul Parvaiz A, Mufti Showkat A, Dhobi G N
Department of Internal and Pulmonary Medicine, SheriKashmir Institute of Medical Sciences, Srinagar, India.
BMJ Case Rep. 2011 Jun 30;2011:bcr0420114149. doi: 10.1136/bcr.04.2011.4149.
A 20-year-old young female presented with extensive skin rashes with bullae and extensive epidermal necrolysis about 20 days after the addition of lamotrigine (LTG) to her anticonvulsant medication. The patient was managed by stopping LTG and supportive treatment. The seizures were controlled with increase in the doses of carbamazepine. The report emphasises exercising of caution once LTG is added to a regimen containing valproic acid.
一名20岁年轻女性在抗惊厥药物中加用拉莫三嗪（LTG）约20天后，出现广泛的水疱性皮肤皮疹和大面积表皮松解。患者通过停用LTG及支持治疗进行处理。癫痫发作通过增加卡马西平剂量得到控制。该报告强调，在含有丙戊酸的治疗方案中加用LTG时需谨慎。
