[拉莫三嗪治疗后发生的中毒性表皮坏死松解症]
[Toxic epidermal necrolysis after treatment with lamotrigine].
作者信息
Zachariae C O, Fogh K
机构信息
Dermatologisk afdeling, Bispebjerg Hospital, København.
出版信息
Ugeskr Laeger. 1998 Nov 9;160(46):6656-7.
PMID:9825684
Abstract
A case of toxic epidermal necrolysis following treatment with lamotrigine is presented. A 20 year old male suffering from epilepsy was treated with lamotrigine in addition to valproic acid. After three weeks he developed cutaneous manifestations of Steven-Johnson's syndrome followed by toxic epidermal necrolysis, mucosal lesions and liver symptoms. He was treated with systemic corticosteroids, antibiotics and intravenous fluid, and recovered after a few weeks.
摘要
报告了1例使用拉莫三嗪治疗后发生中毒性表皮坏死松解症的病例。一名20岁患有癫痫的男性，除丙戊酸外还接受拉莫三嗪治疗。三周后，他出现了史蒂文斯-约翰逊综合征的皮肤表现，随后发展为中毒性表皮坏死松解症、黏膜病变和肝脏症状。他接受了全身性皮质类固醇、抗生素和静脉输液治疗，几周后康复。
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