Mannello F, Bocchiotti G D, Morano F P, Fratepietro L M, Gazzanelli G
Istituto di Istologia ed Analisi di Laboratorio, Facoltà di Scienze M.F.N., Università degli Studi, Urbino (PS), Italy.
Cancer Lett. 1996 Jan 2;98(2):137-43.
Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity and total lipid concentrations were measured in cyst fluids and sera from 89 women affected by gross cystic breast disease. Total cholesterol and high-density lipoprotein content were significantly (P < 0.001) greater in pooled cyst fluids than normal sera. Moreover, data analyses show a significant increase in the mean values of total lipids and lipase activity in metabolically active apocrine cysts, when compared to the flattened cysts (P < 0.001). The lipids feature of apocrine cysts could represent an altered expression of biosynthetic activity of the surrounding apocrine cell surface glycolipid and steroidogenic metabolism and may provide further knowledge about the functional stage changes of gross breast cysts.
乳腺良性巨大囊肿病是最常见的乳腺病变；囊肿内衬上皮有大汗腺化生改变的女性患乳腺癌的风险高于正常人群。对89例患乳腺巨大囊肿病的女性的囊液和血清进行了总胆固醇、高密度脂蛋白和低密度脂蛋白组分、甘油三酯、磷脂、脂肪酶活性及总脂质浓度的检测。合并的囊液中总胆固醇和高密度脂蛋白含量显著高于正常血清（P<0.001）。此外，数据分析显示，与扁平囊肿相比，代谢活跃的大汗腺囊肿的总脂质和脂肪酶活性平均值显著升高（P<0.001）。大汗腺囊肿的脂质特征可能代表周围大汗腺细胞表面糖脂生物合成活性和类固醇生成代谢的改变，可能为乳腺巨大囊肿的功能阶段变化提供更多认识。
