Dzendrowskyj T E, Noyszewski E A, Beers J, Bolinger L
University of Pennsylvania Medical Center, Department of Radiology, Philadelphia 19104, USA.
MAGMA. 1997 Jun;5(2):105-10. doi: 10.1007/BF02592240.
The detection of breast cancer in women using magnetic resonance imaging (MRI) is increasingly used as a supplement to X-ray mammography. Furthermore, proton MR spectroscopy (1H MRS) has detected alterations in lipid profiles that are linked with tumor development and progression in human biopsy tissue. Because normal "resting" breast is highly active, it is necessary to consider that any alterations observed in lipid profiles may not be indicative of breast tumor development. The purpose of this study was to assess the changes in lipid composition in the breast throughout the menstrual cycle in "normals" using MRS at 4.0 T. Five women with no known history of breast disease were subject to biweekly MRS breast examinations. MRS results showing water and fat resonances revealed cyclic changes in the lipid content throughout the duration of the menstrual cycle. In particular, intensity changes were seen in methylene (-CH2-) and allylic methylene (CH2CH2*CH=) resonances at 2.1 ppm and 1.3 ppm, respectively. These intensity changes assumed a similar cyclic trend for each subject over the 28 days that correlate with the follicular, ovulatory, and luteal phases of the menstrual cycle. The results obtained may indicate cell synthesis or metabolic activity in the breast during the menstrual cycle and provide valuable information pertinent to lipid responses associated with breast disease.
利用磁共振成像（MRI）对女性乳腺癌进行检测越来越多地被用作X线乳房造影的补充手段。此外，质子磁共振波谱（1H MRS）已检测到人类活检组织中与肿瘤发生和发展相关的脂质谱变化。由于正常“静息”乳腺高度活跃，因此有必要考虑到脂质谱中观察到的任何变化可能并不表明乳腺肿瘤的发展。本研究的目的是使用4.0 T的磁共振波谱评估“正常”女性在整个月经周期中乳腺脂质成分的变化。对五名无乳腺癌病史的女性进行每两周一次的乳腺磁共振波谱检查。磁共振波谱结果显示水和脂肪共振，揭示了整个月经周期中脂质含量的周期性变化。特别是，在2.1 ppm和1.3 ppm处分别观察到亚甲基（-CH2-）和烯丙基亚甲基（CH2CH2*CH=）共振的强度变化。在与月经周期的卵泡期、排卵期和黄体期相关的28天内，每个受试者的这些强度变化呈现出相似的周期性趋势。所获得的结果可能表明月经周期中乳腺的细胞合成或代谢活性，并提供与乳腺疾病相关的脂质反应有关的有价值信息。
