Krishnamurthy G, Kher V, Naik S
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.
Indian J Med Res. 1995 Dec;102:281-6.
Cellular immune responses were evaluated in 12 early renal failure (ERF) patients who were not on maintenance haemodialysis, 43 end stage renal disease (ESRD) patients on haemodialysis (HD) and 25 healthy volunteers. Peripheral blood mononuclear cells (PBMC) of ERF and ESRD patients on HD had a significantly diminished lymphoproliferative responses to phytohaemagglutinin and a monoclonal antibody to the CD3 (anti-CD3) receptor on T-cells as compared to normals. The interleukin-2 (IL-2) production by the PBMC was also significantly reduced in renal failure patients as compared to normals. These data suggest that both IL-2 dependent and IL-2 independent T-cell functions are defective in renal failure patients.
对12例未进行维持性血液透析的早期肾衰竭（ERF）患者、43例接受血液透析（HD）的终末期肾病（ESRD）患者以及25名健康志愿者的细胞免疫反应进行了评估。与正常人相比，接受HD的ERF和ESRD患者的外周血单个核细胞（PBMC）对植物血凝素和T细胞上CD3受体的单克隆抗体（抗CD3）的淋巴细胞增殖反应显著减弱。与正常人相比，肾衰竭患者PBMC产生的白细胞介素-2（IL-2）也显著减少。这些数据表明，肾衰竭患者中依赖IL-2和不依赖IL-2的T细胞功能均存在缺陷。
