Mäurer J, Knollmann F D, Schlums D, Garbe C, Vogl T J, Bier J, Felix R
Strahlenklinik und Poliklinik, Medizinische Fakultät, Humboldt-Universität zu Berlin, Germany.
Invest Radiol. 1995 Nov;30(11):638-43. doi: 10.1097/00004424-199511000-00003.
The aim of the study was to evaluate the use of high resolution magnetic resonance imaging (MRI) for differentiation of melanin-containing skin tumors.
Twenty-seven melanocytic nevi and 18 malignant melanomas were examined by high resolution MRI. Signal intensities and signal-to-noise (SNR) and contrast-to-noise ratios (CNR) of the tumors were determined in enhanced (T1, T2, water-suppression, and fat-suppression sequences) and contrast-enhanced images (T1 and fat-suppression sequences). The differences were tested for significance by a Wilcoxon test.
Malignant melanomas differed from melanocytic nevi in that they displayed a higher SNR in T2-weight and unenhanced and contrast-enhanced fat-suppression scan. Malignant melanomas exhibited a higher CNR than did benign lesions in unenhanced and contrast-enhanced fat-suppression sequences with dermis as reference tissue (P < 0.05) and in enhanced fat-suppression sequences with subcutis as reference tissue (P < 0.05).
The usefulness of SNR and CNR analysis on MRI for the differentiation of malignant skin tumors from benign skin tumors of the melanin-containing system is limited. Clinical and histologic examinations are, further, the important step in evaluation of melanin-containing skin tumors.
本研究旨在评估高分辨率磁共振成像（MRI）在鉴别含黑色素皮肤肿瘤中的应用。
对27例黑素细胞痣和18例恶性黑色素瘤进行高分辨率MRI检查。在增强图像（T1、T2、水抑制和脂肪抑制序列）和对比增强图像（T1和脂肪抑制序列）中测定肿瘤的信号强度、信噪比（SNR）和对比噪声比（CNR）。采用Wilcoxon检验对差异进行显著性检验。
恶性黑色素瘤与黑素细胞痣的不同之处在于，在T2加权、未增强和对比增强脂肪抑制扫描中，它们显示出更高的SNR。以真皮为参照组织时，在未增强和对比增强脂肪抑制序列中，恶性黑色素瘤的CNR高于良性病变（P < 0.05）；以皮下组织为参照组织时，在增强脂肪抑制序列中，恶性黑色素瘤的CNR也高于良性病变（P < 0.05）。
MRI上的SNR和CNR分析在鉴别含黑色素系统的恶性皮肤肿瘤与良性皮肤肿瘤方面的作用有限。此外，临床和组织学检查是评估含黑色素皮肤肿瘤的重要步骤。
