Schmitz S A, Wagner S, Schuhmann-Giampieri G, Wolf K J
Department of Radiology, Benjamin Franklin University Hospital Steglitz, Free University of Berlin, Germany.
Invest Radiol. 1995 Nov;30(11):644-9. doi: 10.1097/00004424-199511000-00004.
The efficacy of the neutral lanthanide contrast agent gadobutrol was compared to that of the iodinated contrast agent iopromide in rabbits.
The computed tomography (CT) attenuation of increasing concentrations of gadolinium (Gd) (gadobutrol) and iodine (I) (iopromide) was measured in Hounsfield units (HU) in aqueous solution at 80, 120, and 137 kV. The peak enhancement (net increase in CT attenuation compared with baseline) and the time-enhancement product in the aorta and in the renal parenchyma of the outer and inner cortex were measured in rabbits over a 5-minute period after the animals were given single intravenous injections of 0.7, 1.0, and 1.5 mmol Gd/kg of gadobutrol and 1.0 and 2.4 mmol I/kg of iopromide.
In vitro, the CT attenuation of gadolinium was 40% higher than that of iodine at equivalent mass concentrations (120 kV). The mean peak enhancements in the aorta after the injections of 0.7, 1.0, and 1.5 mmol Gd/kg and 1.0 and 2.4 mmol I/kg were 216, 313, 591, 224, and 498 HU, respectively. In addition, a 30-second injection of the high dose of gadobutrol resulted in an attenuation profile that was suitable for a three-dimensional reconstruction of the aorta and the renal vasculature.
Because of the higher CT attenuation of gadolinium compared with that of iodine, the neutral macrocyclic chelate gadobutrol is a more effective contrast agent than iopromide for CT at lower doses of the imaging atom.
在兔体内比较中性镧系元素造影剂钆布醇与碘化造影剂碘普罗胺的疗效。
在80、120和137 kV下，以亨氏单位（HU）测量水溶液中钆（Gd）（钆布醇）和碘（I）（碘普罗胺）浓度增加时的计算机断层扫描（CT）衰减。在动物单次静脉注射0.7、1.0和1.5 mmol Gd/kg钆布醇以及1.0和2.4 mmol I/kg碘普罗胺后的5分钟内，测量主动脉以及肾皮质外层和内层肾实质的峰值增强（与基线相比CT衰减的净增加）和时间增强乘积。
在体外，在等效质量浓度下（120 kV），钆的CT衰减比碘高40%。注射0.7、1.0和1.5 mmol Gd/kg以及1.0和2.4 mmol I/kg后，主动脉的平均峰值增强分别为216、313、591、224和498 HU。此外，高剂量钆布醇30秒的注射产生了适合主动脉和肾血管系统三维重建的衰减曲线。
由于钆的CT衰减高于碘，在较低剂量成像原子的情况下，中性大环螯合物钆布醇作为CT造影剂比碘普罗胺更有效。
