Nikawa H, Yamamoto T, Hamada T
Department of Prosthetic Dentistry, Hiroshima University School of Dentistry, Japan.
J Oral Rehabil. 1995 Nov;22(11):817-24. doi: 10.1111/j.1365-2842.1995.tb00228.x.
Variation in the components of soft lining materials, i.e. the size of polymer particles, the ethyl alcohol content of the liquids and the type of plasticizer, were investigated with respect to their effects on the growth and colonization of Candida albicans. Inhibitory effects on fungal growth and/or acid production were found to vary depending upon the components of soft lining materials. In particular, two plasticizers, benzyl benzoate (BB) and benzyl salicylate (BS), significantly decreased the growth rate, whereas the size of polymer particle had little effect on fungal growth. Ethyl alcohol content of liquid significantly affected the fungal growth and/or acid production depending upon the plasticizer used. For instance, in the case of BS, the antifungal effect was related to ethyl alcohol contents, whereas a reverse effect was observed with benzyl n-butyl phthalate (BBP). Further examination using scanning electron microscopy revealed that Candida blastospores colonized lining materials in the following two ways depending on the plasticizers used. On the BS and dibutyl phthalate (DBP) specimen, the blastospore of this yeast associated loosely, whereas, in the case of BB, BBP and butyl phthalyl butyl glycorate (BPBG), fungal blastospore tightly and invasively colonized onto the specimens. These results clearly demonstrated a relationship between components of soft lining materials and fungal growth and colonization.
研究了软衬材料成分的变化，即聚合物颗粒的大小、液体中的乙醇含量和增塑剂的类型，考察它们对白色念珠菌生长和定植的影响。发现对真菌生长和/或产酸的抑制作用因软衬材料的成分而异。特别是，两种增塑剂苯甲酸苄酯（BB）和水杨酸苄酯（BS）显著降低了生长速率，而聚合物颗粒的大小对真菌生长影响很小。液体中的乙醇含量根据所用增塑剂的不同对真菌生长和/或产酸有显著影响。例如，在BS的情况下，抗真菌作用与乙醇含量有关，而邻苯二甲酸正丁酯（BBP）则观察到相反的效果。使用扫描电子显微镜的进一步检查表明，根据所用增塑剂的不同，白色念珠菌芽生孢子以以下两种方式定植在衬里材料上。在BS和邻苯二甲酸二丁酯（DBP）标本上，这种酵母的芽生孢子松散地附着，而在BB、BBP和丁基邻苯二甲酰丁基甘油酸酯（BPBG）的情况下，真菌芽生孢子紧密且侵入性地定植在标本上。这些结果清楚地证明了软衬材料成分与真菌生长和定植之间的关系。
