[1992年抗菌药物对尿路感染分离病原菌的活性比较研究。II. 患者背景]

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1992). II. Background of patients].

作者信息

Kumamoto Y, Hirose T, Tanaka N, Hikichi Y, Shigeta S, Shiraiwa Y, Kameoka H, Yoshida H, Ogata M, Tazaki H

机构信息

Department of Urology, Sapporo Medical University, School of Medicine.

出版信息

Jpn J Antibiot. 1995 Nov;48(11):1658-70.

PMID:8558755

Abstract

Clinical background was investigated on 913 bacterial strains isolated from patients with urinary tract infections (UTIs) in 11 hospitals during the period from June, 1992 to May, 1993. 1. Distribution of sex, age and infections Among over forties males, the majority was taken by complicated urinary tract infections. Among females, the uncomplicated urinary tract infections was most frequent without a relation of age. 2. Distribution of sex, age and pathogens isolated from UTIs IN uncomplicated UTIs, Escherichia coli was most frequently isolated without a relation of age, and next CNS in under fifties. In complicated UTIs without indwelling catheter, E. coli and Enterococcus faecalis were isolated with a frequency of 12-28%, respectively. In complicated UTIs with indwelling catheter, Pseudomonas aeruginosa were most frequently isolated, and next E. faecalis. 3. Administration of antibiotics and pathogens isolated from UTIs In uncomplicated UTIs, pathogens, after administration of antibiotics, isolated from patients have obviously decreased from 306 to 44 isolates. And also, pathogens of complicated UTIs without indwelling catheter, have decreased from 217 to 76 isolates. However, in complicated UTIs with indwelling catheter, pathogens after or before administration of antibiotics, were not revealed an obvious change. 4. Pathogens and UTIs with or without factor and operation In uncomplicated UTIs with or without factor and operation, E. coli was mainly detected. In complicated UTIs without indwelling catheter and with or without factor and operation, E. coli was mainly detected. In complicated UTIs with indwelling catheter and with factor and operation, P. aeruginosa and E. faecalis were detected, 19.6% and 16.0%, respectively. Without factor and operation, P. aeruginosa was detected, 28.9%, and next E. faecalis 13.3%. The distribution of pathogens after administration of antibiotics was similar.

摘要

对1992年6月至1993年5月期间从11家医院的尿路感染（UTI）患者中分离出的913株细菌菌株进行了临床背景调查。1. 性别、年龄和感染分布在40岁以上男性中，大多数为复杂性尿路感染。在女性中，非复杂性尿路感染最为常见，与年龄无关。2. 从UTI分离出的性别、年龄和病原体分布在非复杂性UTI中，大肠杆菌最常被分离出，与年龄无关，其次是50岁以下的凝固酶阴性葡萄球菌（CNS）。在无留置导管的复杂性UTI中，大肠杆菌和粪肠球菌的分离频率分别为12% - 28%。在有留置导管的复杂性UTI中，铜绿假单胞菌最常被分离出，其次是粪肠球菌。3. 抗生素使用情况与从UTI分离出的病原体在非复杂性UTI中，使用抗生素后，从患者中分离出的病原体明显减少，从306株降至44株。同样，无留置导管的复杂性UTI的病原体也从217株降至76株。然而，在有留置导管的复杂性UTI中，使用抗生素前后的病原体没有明显变化。4. 病原体与有无因素及手术的UTI 在有无因素及手术的非复杂性UTI中，主要检测到大肠杆菌。在无留置导管且有无因素及手术的复杂性UTI中，主要检测到大肠杆菌。在有留置导管且有因素及手术的复杂性UTI中，检测到铜绿假单胞菌和粪肠球菌，分别为19.6%和16.0%。无因素及手术时，检测到铜绿假单胞菌为28.9%，其次是粪肠球菌为13.3%。使用抗生素后病原体的分布相似。