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行为遗传学:语言发展与障碍研究及实践的概念

Behavioral genetics: concepts for research and practice in language development and disorders.

作者信息

Gilger J W

机构信息

University of Kansas, Lawrence, USA.

出版信息

J Speech Hear Res. 1995 Oct;38(5):1126-42. doi: 10.1044/jshr.3805.1126.

Abstract

This paper is an introduction to behavioral genetics for researchers and practitioners in language development and disorders. The specific aims are to illustrate some essential concepts and to show how behavioral genetic research can be applied to the language sciences. Past genetic research on language-related traits has tended to focus on simple etiology (i.e., the heritability or familiality of language skills). The current state of the art, however, suggests that great promise lies in addressing more complex questions through behavioral genetic paradigms. In terms of future goals it is suggested that: (a) more behavioral genetic work of all types should be done--including replications and expansions of preliminary studies already in print; (b) work should focus on fine-grained, theory-based phenotypes with research designs that can address complex questions in language development; and (c) work in this area should utilize a variety of samples and methods (e.g., twin and family samples, heritability and segregation analyses, linkage and association tests, etc.).

摘要

本文是为从事语言发展与障碍研究的科研人员和从业者撰写的行为遗传学入门介绍。具体目标是阐释一些基本概念,并展示行为遗传学研究如何应用于语言科学领域。过去关于语言相关特质的遗传学研究往往聚焦于简单的病因学(即语言技能的遗传性或家族性)。然而,当前的技术水平表明,通过行为遗传学范式解决更复杂的问题具有巨大潜力。就未来目标而言,建议如下:(a)应开展更多各类行为遗传学研究——包括对已发表的初步研究进行重复和扩展;(b)研究应聚焦于基于理论的精细表型,采用能够解决语言发展中复杂问题的研究设计;(c)该领域的研究应采用多种样本和方法(如双胞胎和家庭样本、遗传度和分离分析、连锁和关联测试等)。

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