Rubalcava M A, Sotelo J
National Institute of Neurology and Neurosurgery of Mexico, Mexico City.
Neurosurgery. 1995 Oct;37(4):668-71; discussion 671-2. doi: 10.1227/00006123-199510000-00009.
We studied ventricular and lumbar cerebrospinal fluid (CSF) in 16 patients with hydrocephalus secondary to meningeal cysticercosis, and samples were taken at the time of the surgical implantation of a ventricular shunt. All lumbar CSF samples revealed raised cell counts (mean, 72 +/- 28/mm3) and protein counts (mean, 78 +/- 12 mg/dl), as well as positive immune reactions to cysticerci antigens. In contrast, 50% of the ventricular CSF samples exhibited cell and protein counts within normal limits and five showed negative immune reactions to cysticerci antigens. Ample differences between ventricular and lumbar CSF were also observed in the contents of glucose and immunoglobulins G, A, and M. The biochemical and immunological composition of the CSF varied greatly along the cerebrospinal axis in patients with chronic arachnoiditis caused by cysticercosis. Our findings further support the premise of the subarachnoid space as an immunologically active substratum and provide information to explain the frequent occlusion of ventricular shunts in patients with hydrocephalus secondary to inflammatory disorders of the subarachnoid space.
我们研究了16例继发于脑膜囊尾蚴病的脑积水患者的脑室和腰椎脑脊液（CSF），并在脑室分流手术植入时采集样本。所有腰椎脑脊液样本均显示细胞计数升高（平均72±28/mm³）、蛋白计数升高（平均78±12mg/dl），以及对囊尾蚴抗原的阳性免疫反应。相比之下，50%的脑室脑脊液样本细胞和蛋白计数在正常范围内，5例对囊尾蚴抗原呈阴性免疫反应。在葡萄糖和免疫球蛋白G、A和M的含量方面，脑室和腰椎脑脊液之间也观察到显著差异。在由囊尾蚴病引起的慢性蛛网膜炎患者中，脑脊液的生化和免疫组成沿脑脊髓轴有很大差异。我们的研究结果进一步支持了蛛网膜下腔作为免疫活性基质的前提，并提供了信息来解释继发于蛛网膜下腔炎症性疾病的脑积水患者脑室分流管频繁堵塞的原因。
