当脑室脑脊液评估产生误导时：基底脑膜炎及腰椎穿刺采样的重要性
When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling.
作者信息
Khan Sadid F, Macauley Thornton, Tong Steven Y C, Xie Ouli, Hughes Carly, Hall Nicholas D P, Mahanty Siddhartha, Jennens Ian, Street Alan C
机构信息
Victorian Infectious Disease Service, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Doherty Department University of Melbourne, Peter Doherty Institute for Infection and Immunity, Victoria, Australia.
出版信息
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz324.
The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.
中枢神经系统（CNS）感染的诊断依赖于脑脊液（CSF）分析。我们报告4例与基底脑膜炎和脑积水相关的CNS感染病例，其脑室CSF正常，但腰椎CSF明显异常。我们讨论了CSF脑室-腰椎成分梯度及可能的病理生理机制，并为临床医生强调临床线索。
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