Bril V, Ilse W K, Pearce R, Dhanani A, Sutton D, Kong K
University of Toronto, Ontario, Canada.
Neurology. 1996 Jan;46(1):100-3. doi: 10.1212/wnl.46.1.100.
We compared intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) in the treatment of 50 patients with Guillain-Barré syndrome (GBS). Standard outcome measures did not differ for the two groups. Sixty-one percent of the PLEX-treated group and 69% of the IVIG-treated group improved by one disability grade at 1 month. The complication rate was higher in the PLEX-treated group. We conclude that the efficacy of IVIG in the treatment of GBS is comparable with that of PLEX and that it can be used safely, although we had a small number of patients. We did not observe a higher relapse rate with IVIG. The usefulness of combination therapy is unknown at this time.
我们比较了静脉注射免疫球蛋白（IVIG）和血浆置换（PLEX）对50例吉兰-巴雷综合征（GBS）患者的治疗效果。两组的标准结局指标无差异。血浆置换治疗组有61%的患者以及静脉注射免疫球蛋白治疗组有69%的患者在1个月时残疾等级改善了一级。血浆置换治疗组的并发症发生率更高。我们得出结论，静脉注射免疫球蛋白治疗GBS的疗效与血浆置换相当，并且尽管我们的患者数量较少，但它可以安全使用。我们未观察到静脉注射免疫球蛋白治疗有更高的复发率。目前联合治疗的有效性尚不清楚。
