Giusto M D, Lambiasi A, Cantonetti G, Morini A
Università degli Studi di Roma La Sapienza, Dipartimento di Scienze Psichiatriche e Medicina Psicologica.
Minerva Ginecol. 1995 Jul-Aug;47(7-8):319-25.
The authors have attempted to evaluate the extent to which menopausal crisis is linked to hypoestrogenism and the extent to which it is linked to the socioenvironmental context in which it takes place. The study analyses emotional and cognitive aspects in a group of women in temporary menopause which was pharmacologically induced for therapeutic purposes. The study was carried out in 30 patients suffering from benign gynecological pathologies receiving ovarian steroidogenesis-blocking treatment. Treatment consisted of a subcutaneous administration of a Gn-Rh analog every 28 days for 6 months. After having collected information regarding the symptoms that appeared following the administration of therapy, the authors evaluated the emotive (anxiety and depression) and cognitive (short-term memory and concentration) conditions of patients using psychometric reactives performed during the first check-up, and then repeated at the 3rd, 5th and 7th control visit: the State-Trait-Anxiety-Inventory to assess trait anxiety and state anxiety; scale D of the Minnesota Multiphasic Personality Inventory to assess depression; the sub-test for memory of figures from Wechsler-Bellevue Intelligence Scale to evaluate short-term memory; the Toulouse-Pieron reactive to evaluate attention and concentration. The results obtained were analysed statistically using Student's t-test and Pearson's coefficient. An analysis of the data shows that, after the first doses of the drug stress trends to diminish from the high levels recorded at the first visit, stabilising at normal values throughout treatment. Like anxiety and depression, concentration and memory do not show marked variations.(ABSTRACT TRUNCATED AT 250 WORDS)
作者试图评估更年期危机与雌激素缺乏的关联程度,以及它与发生时的社会环境背景的关联程度。该研究分析了一组因治疗目的而药物诱导进入暂时更年期的女性的情绪和认知方面。研究针对30名患有良性妇科疾病并接受卵巢类固醇生成阻断治疗的患者展开。治疗方案为每28天皮下注射一次Gn-Rh类似物,持续6个月。在收集了治疗后出现的症状信息后,作者使用首次检查时进行的心理测量反应指标评估患者的情绪(焦虑和抑郁)和认知(短期记忆和注意力)状况,然后在第3次、第5次和第7次对照访视时重复评估:使用状态-特质焦虑量表评估特质焦虑和状态焦虑;使用明尼苏达多相人格调查表D量表评估抑郁;使用韦克斯勒-贝尔维尤智力量表中的数字记忆子测试评估短期记忆;使用图卢兹-皮埃隆反应指标评估注意力和专注力。使用学生t检验和皮尔逊系数对所得结果进行统计学分析。数据分析表明,首次用药后,应激趋势从首次访视时记录的高水平开始下降,在整个治疗过程中稳定在正常水平。与焦虑和抑郁一样,注意力和记忆力也没有明显变化。(摘要截选至250词)