Hendrick D A, Meyers A
Department of Otolaryngology-Head & Neck Surgery, University of Colorado Health Science Center, Denver 80262-0001, USA.
Otolaryngol Clin North Am. 1995 Oct;28(5):969-86.
Compared with scalpel wounds, CO2 laser wounds show delays in inflammation, collagen production, reepithelialization, and tensile strength in the early stages of healing. Some of these delays are similar to those seen with electrocautery and burn wounds. Later stages compensate for these early deficiencies, because scalpel and laser wounds become more similar in epithelialization and wound strength over time. Healed CO2 laser wounds tend to have less scar contraction than scalpel wounds. Débridement of initial laser wound char, tissue cooling techniques during lasering, and pulsed modes of laser delivery all seem to result in more rapid, favorable healing. Similar wound healing trends have been seen with the CO2 laser in bone, with other lasers, and with laser vascular and neural anastomosis. Biostimulation with low-level laser energy is a complex subject of ongoing investigations.
与手术刀伤口相比，二氧化碳激光伤口在愈合早期的炎症、胶原蛋白生成、再上皮化和抗张强度方面会出现延迟。其中一些延迟与电灼和烧伤伤口相似。后期阶段弥补了这些早期缺陷，因为随着时间的推移，手术刀伤口和激光伤口在上皮化和伤口强度方面变得更加相似。愈合后的二氧化碳激光伤口往往比手术刀伤口的瘢痕收缩更少。初始激光伤口焦痂的清创、激光治疗期间的组织冷却技术以及激光发射的脉冲模式似乎都能带来更快、更好的愈合。在骨骼、其他激光以及激光血管和神经吻合术中，二氧化碳激光也出现了类似的伤口愈合趋势。低强度激光能量的生物刺激是一个正在进行研究的复杂课题。
