奈替米星与庆大霉素：人体中的比较药理学
Netilmicin and gentamicin: comparative pharmacology in humans.
作者信息
Riff L J, Moreschi G
出版信息
Antimicrob Agents Chemother. 1977 Apr;11(4):609-14. doi: 10.1128/AAC.11.4.609.
Abstract
Thirteen male subjects received 1 mg of either gentamicin or netilmicin per kg, first intramuscularly and then intravenously. After the intramuscular dose, concentrations of gentamicin in the serum were more variable than those of netilmicin. After the intravenous dose, the distribution phase of netilmicin was twice as rapid as gentamicin. The average half-times of the elimination phase were similar, but there was marked variability among the subjects receiving gentamicin. Serum clearance of netilmicin was more rapid than that of gentamicin and could not be attributed to renal elimination. The data indicate that, after intramuscular administration, netilmicin may produce more predictable blood levels than gentamicin and suggest that the body distribution of netilmicin may differ from that of gentamicin.
摘要
13名男性受试者每千克体重接受1毫克庆大霉素或奈替米星，先肌肉注射，然后静脉注射。肌肉注射剂量后，血清中庆大霉素的浓度比奈替米星的浓度变化更大。静脉注射剂量后，奈替米星的分布阶段比庆大霉素快两倍。消除阶段的平均半衰期相似，但接受庆大霉素的受试者之间存在明显差异。奈替米星的血清清除率比庆大霉素更快，且不能归因于肾脏清除。数据表明，肌肉注射后，奈替米星可能比庆大霉素产生更可预测的血药浓度，并提示奈替米星的体内分布可能与庆大霉素不同。
相似文献
1
Netilmicin and gentamicin: comparative pharmacology in humans.奈替米星与庆大霉素：人体中的比较药理学
Antimicrob Agents Chemother. 1977 Apr;11(4):609-14. doi: 10.1128/AAC.11.4.609.
2
Kinetics of netilmicin and gentamicin.奈替米星和庆大霉素的动力学
Clin Pharmacol Ther. 1978 May;23(5):591-7. doi: 10.1002/cpt1978235591.
3
Renal pharmacology of netilmicin.奈替米星的肾脏药理学
Antimicrob Agents Chemother. 1977 May;11(5):821-5. doi: 10.1128/AAC.11.5.821.
4
Comparative nephrotoxicities of netilmicin and gentamicin in rats.奈替米星和庆大霉素对大鼠的肾毒性比较
Antimicrob Agents Chemother. 1976 Nov;10(5):845-9. doi: 10.1128/AAC.10.5.845.
5
Kinetics of netilmicin in man.奈替米星在人体中的动力学。
Clin Pharmacol Ther. 1978 Jun;23(6):677-84. doi: 10.1002/cpt1978236677.
6
Comparative clinical pharmacology of gentamicin, sisomicin, and tobramycin.庆大霉素、西索米星和妥布霉素的比较临床药理学
Antimicrob Agents Chemother. 1975 Oct;8(4):396-401. doi: 10.1128/AAC.8.4.396.
7
Clinical pharmacology of sisomicin.西索米星的临床药理学。
Antimicrob Agents Chemother. 1975 Jan;7(1):38-41. doi: 10.1128/AAC.7.1.38.
8
Comparative distribution of gentamicin, tobramycin, sisomicin, netilmicin, and amikacin in interstitial fluid in rabbits.庆大霉素、妥布霉素、西索米星、奈替米星和阿米卡星在兔间质液中的比较分布。
Antimicrob Agents Chemother. 1978 Mar;13(3):368-72. doi: 10.1128/AAC.13.3.368.
9
Netilmicin pharmacokinetics after single intravenous doses to elderly male patients.奈替米星单次静脉给药后在老年男性患者中的药代动力学。
Antimicrob Agents Chemother. 1977 Sep;12(3):328-34. doi: 10.1128/AAC.12.3.328.
10
Comparison of netilmicin and gentamicin pharmacokinetics in humans.奈替米星与庆大霉素在人体中的药代动力学比较。
Antimicrob Agents Chemother. 1980 Feb;17(2):184-7. doi: 10.1128/AAC.17.2.184.
引用本文的文献
1
Comparison of netilmicin and gentamicin pharmacokinetics in humans.奈替米星与庆大霉素在人体中的药代动力学比较。
Antimicrob Agents Chemother. 1980 Feb;17(2):184-7. doi: 10.1128/AAC.17.2.184.
2
Predicted tissue accumulation of netilmicin in patients.奈替米星在患者体内的预测组织蓄积情况。
Antimicrob Agents Chemother. 1981 Dec;20(6):714-7. doi: 10.1128/AAC.20.6.714.
3
Pharmacokinetic assessment of netilmicin in newborns and older children.奈替米星在新生儿和大龄儿童中的药代动力学评估。
Infection. 1982;10(3):153-8. doi: 10.1007/BF01640766.
4
Assay of netilmicin, using enzyme immunoassay for gentamicin.使用庆大霉素酶免疫测定法测定奈替米星。
Antimicrob Agents Chemother. 1982 Mar;21(3):399-401. doi: 10.1128/AAC.21.3.399.
5
Prospective comparative study of efficacy and toxicity of netilmicin and amikacin.奈替米星与阿米卡星疗效及毒性的前瞻性对照研究
Antimicrob Agents Chemother. 1980 Feb;17(2):217-25. doi: 10.1128/AAC.17.2.217.
6
Clinical pharmacology of netilmicin in the newborn.奈替米星在新生儿中的临床药理学
Arch Dis Child. 1983 Jun;58(6):451-3. doi: 10.1136/adc.58.6.451.
7
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.囊性纤维化中抗生素及其他药物的临床药理学
Drugs. 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004.
8
Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.奈替米星。对其抗菌活性、药代动力学特性及治疗用途的综述。
Drugs. 1989 Nov;38(5):703-56. doi: 10.2165/00003495-198938050-00003.
9
Clinical pharmacology of netilmicin.奈替米星的临床药理学
Antimicrob Agents Chemother. 1977 Dec;12(6):717-20. doi: 10.1128/AAC.12.6.717.
10
High-pressure liquid chromatographic assay of netilmicin in plasma.血浆中奈替米星的高压液相色谱测定法。
Antimicrob Agents Chemother. 1977 Dec;12(6):707-9. doi: 10.1128/AAC.12.6.707.
本文引用的文献
1
The mild hemophilias. Occult deficiencies of AHF, PTC and PTA frequently responsible for unexpected surgical bleeding.轻型血友病。AHF、PTC和PTA的隐匿性缺乏常导致意外手术出血。
Am J Med. 1961 Jan;30:84-94. doi: 10.1016/0002-9343(61)90065-1.
2
Absorption of atropine from muscle.阿托品从肌肉的吸收。
Am J Physiol. 1957 Dec;191(3):591-4. doi: 10.1152/ajplegacy.1957.191.3.591.
3
Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic.抗生素6640，一种新的由小单孢菌产生的氨基糖苷类抗生素。
J Antibiot (Tokyo). 1970 Nov;23(11):551-4. doi: 10.7164/antibiotics.23.551.
4
Pharmacology of gentamicin in man.庆大霉素在人体中的药理学。
J Infect Dis. 1971 Dec;124 Suppl:S98-105. doi: 10.1093/infdis/124.supplement_1.s98.
5
Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia.对患有癌症和粒细胞减少症的发热患者采用羧苄青霉素和庆大霉素进行经验性治疗。
N Engl J Med. 1971 May 13;284(19):1061-5. doi: 10.1056/NEJM197105132841904.
6
The unpredictability of serum concentrations of gentamicin: pharmacokinetics of gentamicin in patients with normal and abnormal renal function.庆大霉素血清浓度的不可预测性：肾功能正常和异常患者的庆大霉素药代动力学
J Infect Dis. 1974 Aug;130(2):150-4. doi: 10.1093/infdis/130.2.150.
7
Studies on tolerance and blood levels of gentamicin in old subjects.老年受试者对庆大霉素的耐受性及血药浓度研究。
Int J Clin Pharmacol. 1974 Sep;10(2):95-100.
8
Comparative pharmacokinetics of amikacin and kanamycin.阿米卡星和卡那霉素的比较药代动力学
Clin Pharmacol Ther. 1974 Jun;15(6):610-6. doi: 10.1002/cpt1974156610.
9
Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis.严重革兰氏阴性菌败血症治疗期间监测庆大霉素治疗的经验。
Br Med J. 1974 Mar 16;1(5906):477-81. doi: 10.1136/bmj.1.5906.477.
10
Prospective comparative study of variable dosage and variable frequency regimens for administration of gentamicin.庆大霉素不同剂量和不同给药频率方案的前瞻性对比研究
Antimicrob Agents Chemother. 1975 Oct;8(4):434-8. doi: 10.1128/AAC.8.4.434.
Zotero 插件