Morrell M J, Badr M S, Harms C A, Dempsey J A
William S. Middleton Memorial Veterans Hospital, Department of Medicine, Madison, Wisconsin, USA.
Sleep. 1995 Oct;18(8):651-8. doi: 10.1093/sleep/18.8.651.
We investigated the relationship between airway patency and the occurrence of cardiogenic related oscillations in the airflow signal during 67 apneas occurring in non-rapid eye movement sleep in eight subjects. Spontaneously occurring apneas and apneas induced by mechanical ventilation were analyzed. Airway occlusion was determined by direct observation of the pharyngeal lumen using fiberoptic endoscopy. The presence or absence of cardiogenic oscillations was determined from an expanded airflow signal by an investigator blinded to the airway patency. Of the total 67 apneas, complete airway occlusion occurred during 51, and the airway remained patent throughout in 16. Cardiogenic oscillations were seen throughout 39 of the 51 occluded apneas and throughout 9 of the 16 apneas with the airway patent. There was no relationship between the occurrence of cardiogenic oscillations and airway patency. In addition, in a canine model where the upper airway was anatomically isolated, cardiogenic oscillations were evident during apneas in pressure signals recorded from the isolated upper airway and in airflow signals at the tracheal stoma. We conclude that cardiogenic oscillations cannot be used to predict airway patency during apnea.
我们研究了8名受试者非快速眼动睡眠期间67次呼吸暂停时气道通畅性与气流信号中心源性相关振荡发生之间的关系。对自然发生的呼吸暂停和机械通气诱发的呼吸暂停进行了分析。通过使用纤维内镜直接观察咽腔来确定气道阻塞情况。由对气道通畅情况不知情的研究人员根据扩展的气流信号来确定是否存在心源性振荡。在总共67次呼吸暂停中，51次期间出现完全气道阻塞，16次期间气道全程保持通畅。在51次阻塞性呼吸暂停中的39次以及气道通畅的16次呼吸暂停中的9次全程均可见心源性振荡。心源性振荡的发生与气道通畅性之间无关联。此外，在一个解剖学上分离上气道的犬类模型中，从分离的上气道记录的压力信号以及气管造口处的气流信号在呼吸暂停期间心源性振荡明显。我们得出结论，心源性振荡不能用于预测呼吸暂停期间的气道通畅情况。
