人血清和组织间液中羧苄青霉素、替卡西林、头孢噻吩、头孢唑林、头孢孟多、庆大霉素、妥布霉素和阿米卡星的水平。
Levels of carbenicillin, ticarcillin, cephalothin, cefazolin, cefamandole, gentamicin, tobramycin, and amikacin in human serum and interstitial fluid.
作者信息
Tan J S, Salstrom S J
出版信息
Antimicrob Agents Chemother. 1977 Apr;11(4):698-700. doi: 10.1128/AAC.11.4.698.
Abstract
The ability of eight antibiotics (carbenicillin, ticarcillin, cefamandole, cephalothin, cefazolin, gentamicin, tobramycin, and amikacin) to enter human interstitial fluid was evaluated by the skin window technique. All of the antibiotics tested, except cefazolin, which has the highest percentage of protein binding, diffused into the interstitial fluid quite well. This study confirms our previous observation on the effect of high-percentage protein binding on diffusion of a drug into the minimally inflamed extravascular space.
摘要
采用皮肤窗技术评估了8种抗生素（羧苄青霉素、替卡西林、头孢孟多、头孢噻吩、头孢唑林、庆大霉素、妥布霉素和阿米卡星）进入人体组织间液的能力。除蛋白结合率最高的头孢唑林外，所有受试抗生素均能很好地扩散到组织间液中。本研究证实了我们之前关于高百分比蛋白结合对药物扩散到轻度炎症血管外间隙影响的观察结果。
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