Van den Ingh T S, Rothuizen J, Meyer H P
Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Vet Rec. 1995 Oct 21;137(17):424-7. doi: 10.1136/vr.137.17.424.
Portal hypertension caused by primary hypoplasia of the portal vein was diagnosed in 42 dogs. The portal hypertension was manifested by the presence of multiple portosystemic collateral vessels. The main clinical signs were retarded growth or weight loss, apathy, intermittent diarrhoea and vomiting, anorexia, abdominal distension and polydipsia. Major findings at physical examination were ascites in 23 dogs and neurological signs in 16 dogs. The dogs had increased activities of liver enzymes in plasma and increased fasting levels of total bile acids and ammonia; in many of the dogs the packed red cell volume, total serum protein and albumin were low. Gross inspection of the portal vein revealed a patent but underdeveloped extrahepatic vein in 13 of the dogs. Microscopic examination of the liver revealed hypoplasia of the intrahepatic portal veins in all the dogs, and this was associated with minor arteriolar proliferation and absence of fibrosis in 12 of them, with moderate to marked arteriolar proliferation often combined with ductular proliferation in 13, and with marked portal fibrosis (formerly described as hepatoportal fibrosis) with a varying number of arteriolar and bile ductular structures in 17 of the dogs. The disease affected mainly young dogs, and was most likely to have been of congenital origin.
42只犬被诊断为门静脉原发性发育不全所致的门静脉高压。门静脉高压表现为存在多条门体侧支血管。主要临床症状为生长发育迟缓或体重减轻、冷漠、间歇性腹泻和呕吐、厌食、腹胀和多饮。体格检查的主要发现是23只犬有腹水，16只犬有神经症状。这些犬血浆中肝酶活性升高，空腹总胆汁酸和氨水平升高；许多犬的红细胞压积、总血清蛋白和白蛋白水平较低。对门静脉的大体检查发现，13只犬的肝外静脉通畅但发育不全。对肝脏的显微镜检查发现，所有犬的肝内门静脉均发育不全，其中12只犬伴有小动脉轻度增生且无纤维化，13只犬伴有中度至重度小动脉增生，常伴有小胆管增生，17只犬伴有明显的门静脉纤维化（以前称为肝门静脉纤维化），伴有数量不等的小动脉和胆管结构。该疾病主要影响幼犬，很可能是先天性起源。
