Wanschitz J, Schmidbauer M, Maier H, Rössler K, Vorkapic P, Budka H
Institute of Neurology, University of Vienna, Austria.
Acta Neuropathol. 1995;90(5):539-44. doi: 10.1007/BF00294817.
A 24-year-old female presented with a 3-year history of a suprasellar and intraventricular solid midline process measuring about 3 x 4 cm. At surgery, this tumour was sharply delineated and of stone-like firmness and was removed completely. Histology suggested meningioma, featuring nests and cords of epithelium-like cells with prominent cytoplasm amidst abundant fibrous stroma with prominent lymphoplasmocellular infiltration. Immunocytochemically, the tumour cells expressed vimentin, S-100 protein, epithelial membrane antigen, cytokeratins, and most surprisingly, glial fibrillary acidic protein (GFAP). Ultrastructural investigation revealed abundant intermediate filaments and occasionally dense secretory granules in tumour cells with short, finger-like cytoplasmic processes joined by very rare small, but well-developed desmosomes. This tumour most likely represents a peculiar variant of meningioma with prominent production of GFAP, as previously described [Budka H (1986) Acta Neuropathol (Berl) 72: 43-54].
一名24岁女性，有一个位于鞍上和脑室内的实性中线肿物，病史3年，大小约3×4厘米。手术中，该肿瘤界限清晰，质地如石，被完整切除。组织学检查提示为脑膜瘤，其特征为上皮样细胞巢和条索，胞质突出，位于丰富的纤维性间质中，伴有显著的淋巴浆细胞浸润。免疫细胞化学检查显示，肿瘤细胞表达波形蛋白、S-100蛋白、上皮膜抗原、细胞角蛋白，最令人惊讶的是，还表达胶质纤维酸性蛋白（GFAP）。超微结构研究显示，肿瘤细胞中有丰富的中间丝，偶尔可见密集的分泌颗粒，细胞有短的指状胞质突起，通过非常罕见的小而发育良好的桥粒相连。该肿瘤很可能代表一种特殊类型的脑膜瘤，具有显著的GFAP表达，如先前所述[Budka H（1986年）《神经病理学学报（柏林）》72：43-54]。
