Pollard V, Prough D S, DeMelo A E, Deyo D J, Uchida T, Stoddart H F
Department of Anesthesiology, University of Texas Medical Branch, Galveston 77555-0591, USA.
Anesth Analg. 1996 Feb;82(2):269-77. doi: 10.1097/00000539-199602000-00010.
Cerebral oximeters based on near-infrared spectroscopy may provide a continuous, noninvasive assessment of cerebral oxygenation. We evaluated a prototype cerebral oximeter (Invos 3100; Somanetics, Troy, MI) in 22 conscious, healthy volunteers breathing hypoxic gas mixtures. Using the first 12 subjects (training group), we developed an algorithm based on the mathematic relationship that converts detected light from the field surveyed by the probe to cerebral hemoglobin oxygen saturation (CSfO2). To develop the algorithm, we correlated the oximeter result with the estimated combined brain hemoglobin oxygen saturation (CScombO2, where CScombO2 = SaO2 x 0.25 + SjO2 x 0.75 and SjO2 = jugular venous saturation). We then validated the algorithm in the remaining 10 volunteers (validation group). A close association (r2 = 0.798-0.987 for individuals in the training group and r2 = 0.794-0.992 for individuals in the validation group) existed between CSfO2 and CScombO2. We conclude that continuous monitoring with cerebral oximetry may accurately recognize decreasing cerebral hemoglobin oxygen saturation produced by systemic hypoxemia.
基于近红外光谱技术的脑血氧仪可对脑氧合进行连续、无创评估。我们在22名呼吸低氧混合气体的清醒健康志愿者中对一款脑血氧仪原型（Invos 3100；Somanetics公司，密歇根州特洛伊市）进行了评估。利用前12名受试者（训练组），我们基于将探头探测区域内检测到的光转换为脑血红蛋白氧饱和度（CSfO2）的数学关系开发了一种算法。为开发该算法，我们将血氧仪结果与估计的联合脑血红蛋白氧饱和度（CScombO2，其中CScombO2 = SaO2×0.25 + SjO2×0.75，SjO2 = 颈静脉饱和度）进行了关联。然后我们在其余10名志愿者（验证组）中对该算法进行了验证。CSfO2与CScombO2之间存在密切关联（训练组个体的r2 = 0.798 - 0.987，验证组个体的r2 = 0.794 - 0.992）。我们得出结论，用脑血氧测定法进行连续监测可准确识别由全身性低氧血症导致的脑血红蛋白氧饱和度降低。
