McNeilly F, Smyth J A, Adair B M, McNulty M S
Department of Agriculture for Northern Ireland, Veterinary Sciences Division, Belfast, Northern Ireland.
Avian Dis. 1995 Jul-Sep;39(3):532-7.
One-day-old specific-pathogen-free white leghorn chicks were dually infected with the Cux-1 isolate of chicken anemia virus (CAV) and separate avian reovirus strains (S1133 or Uchida) by an oral route. Fourteen days after inoculation, chicks were bled, and packed cell volumes (PCVs) were determined. Chicks were also weighted and examined for macroscopic changes to the bone marrow, thymus, and bursa of Fabricius. The results obtained following dual inoculation of chicks with CAV and reovirus were compared with results obtained from mock-infected chicks or chicks inoculated with CAV or reovirus alone. Chicks dually infected with CAV and the S1133 reovirus strain had significantly (P < 0.05) lower weight gain and more severe tissue damage than chicks inoculated with either virus alone. In addition, a significant (P < 0.05) reduction in the mean PCV was seen in these dually infected chicks when compared with chicks inoculated with CAV alone. No increase in the severity of the disease signs was observed following dual infection with CAV and reovirus strain Uchida.
一日龄无特定病原体的白来航鸡雏经口双重感染鸡贫血病毒（CAV）的Cux-1分离株和不同的禽呼肠孤病毒株（S1133或内田株）。接种后14天，采集雏鸡血液，测定血细胞压积（PCV）。还对雏鸡进行称重，并检查骨髓、胸腺和法氏囊的宏观变化。将雏鸡双重接种CAV和呼肠孤病毒后的结果与 mock 感染雏鸡或单独接种CAV或呼肠孤病毒的雏鸡的结果进行比较。与单独接种任何一种病毒的雏鸡相比，双重感染CAV和S1133呼肠孤病毒株的雏鸡体重增加显著降低（P < 0.05），组织损伤更严重。此外，与单独接种CAV的雏鸡相比，这些双重感染的雏鸡平均PCV显著降低（P < 0.05）。双重感染CAV和内田呼肠孤病毒株后未观察到疾病症状严重程度增加。
