Yang G Q, Xia Y M
Department of Trace Element Nutrition, Chinese Academy of Preventive Medicine, Beijing, China.
Biomed Environ Sci. 1995 Sep;8(3):187-201.
The human dietary selenium requirement in China has been estimated by various methods. The minimum dietary selenium requirement for the prevention of Keshan disease (KD) was found to be around 17 micrograms/d. On the other hand, an intake of 40 micrograms/d is required to maintain the plasma glutathione peroxidase (GPx) activity at plateau. Hence 40 micrograms/d is considered as the adequate dietary selenium requirement. Studies conducted in a chronic selenosis area indicate that the toxic dietary selenium intake (adverse effect level), which would maintain the characteristic fingernail changes, was approximately 1600 micrograms/d. The mean value of dietary selenium intakes, which enabled the five patients to recover from fingernail lesions, was found to be 819 +/- 126 micrograms/d. At a 95% confidence limit, the lower limit is around 600 micrograms/d. Therefore, 600 and 400 micrograms/d were suggested as the individual daily maximum safe selenium intake and the safe dietary selenium intake, respectively. The results were used in the prevention of Se-related endemic KD and Kashin-Beck disease (KBD).
中国已通过多种方法估算出人体膳食硒需求量。预防克山病（KD）的最低膳食硒需求量约为17微克/天。另一方面，需要摄入40微克/天才能使血浆谷胱甘肽过氧化物酶（GPx）活性维持在稳定水平。因此，40微克/天被视为膳食硒的适宜需求量。在一个慢性硒中毒地区进行的研究表明，会导致典型指甲病变的膳食硒中毒摄入量（不良反应水平）约为1600微克/天。使5名患者指甲病变得以恢复的膳食硒摄入量平均值为819±126微克/天。在95%置信区间，下限约为600微克/天。因此，建议个体每日最大安全硒摄入量和安全膳食硒摄入量分别为600微克/天和400微克/天。这些结果被用于预防与硒相关的地方性克山病和大骨节病（KBD）。
