Rao P V, Bhattacharya R, Pant S C, Bhaskar A S
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.
Biomed Environ Sci. 1995 Sep;8(3):254-64.
Laboratory cultures of freshwater cyanobacterium (blue-green alga) Microcystic aeruginosa PCC 7806 was evaluated for its hepatotoxic effects in rats. The lyophilized cell extract injected intraperitoneally at 1 and 2 LD50 (15.8 and 31.6 mg/kg, respectively) produced significant increase in liver-specific enzymes viz. plasma alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase with a concomitant decrease in hepatic glutamic pyruvic transaminase. A corresponding increase in liver body weight index and histopathological changes in liver (degeneration of hepatocytes, congestion and hemorrhage etc.) are indicative of a dose and time dependent hepatotoxic nature of the algal extract.
对淡水蓝藻（蓝绿藻）铜绿微囊藻PCC 7806的实验室培养物进行了大鼠肝毒性作用评估。以1和2个半数致死剂量（分别为15.8和31.6毫克/千克）腹腔注射冻干细胞提取物后，肝脏特异性酶即血浆碱性磷酸酶、γ-谷氨酰转移酶、乳酸脱氢酶显著升高，同时肝谷丙转氨酶降低。肝脏体重指数相应增加以及肝脏组织病理学变化（肝细胞变性、充血和出血等）表明藻类提取物具有剂量和时间依赖性肝毒性。
