Echenique Elizondo M, Amondarain Arratibel J, Lirón de Robles Sanz C
Universidad del País Vasco, Unidad Docente de Medicina, San Sebastián.
Rev Esp Enferm Dig. 1995 Dec;87(12):843-8.
A series of 84 patients operated on for colorrectal cancer-Duke's stages A:6, B:22, C:51 and D:5- are studied prospectively and with a 5 year follow-up. All of them were treated in the same hospital and with identical criteria during a period of time of two years. Immunoglobulins (A, G, M) and skin reactivity measured through a multiantigen device were determined preoperatively and at 48 hours and 30 days after operation. Data analysis was done once real survival at 5 years was known. Immunoglobulins changes showed no significance in relation to survival in this series. Preoperative skin reactivity values measured in mms demonstrated prognostic significance for patients in stage C when considering survivors -p < 0.05- and decreased -p < 0.01- at five years. Numerical values of skin reactivity done with a delayed hypersensitivity multiantigen compound may represent and additional prognostic factor to be considered in advanced colorrectal cancer patients.
对84例接受结直肠癌手术的患者进行了前瞻性研究，并进行了5年随访，这些患者的杜克分期为：A期6例、B期22例、C期51例和D期5例。他们均在同一家医院接受治疗，且在两年时间内采用相同的标准。术前、术后48小时和30天测定免疫球蛋白（A、G、M）以及通过多抗原装置测量的皮肤反应性。在得知5年实际生存率后进行数据分析。该系列研究中，免疫球蛋白变化与生存率无关。术前以毫米为单位测量的皮肤反应性值，对于C期患者的生存具有预后意义（考虑幸存者时，p<0.05），且在5年时降低（p<0.01）。使用迟发型超敏多抗原复合物测定的皮肤反应性数值可能是晚期结直肠癌患者需考虑的另一个预后因素。
