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[有无腹水的肝硬化对通气力学的影响]

[Influence of liver cirrhosis with and without ascites on ventilatory mechanics].

作者信息

Ordiales Fernández J J, Fernández Moya A, Nistal de Paz F, Linares Rodríguez A, Colubi Colubi L, Alvarez Asensio E, Rodrigo Sáez L

机构信息

Sección de Neumología, Complejo Hospitalario de León.

出版信息

Rev Esp Enferm Dig. 1995 Dec;87(12):853-7.

PMID:8562190
Abstract

BACKGROUND

The thoracic cavity plays an important role in the mechanical ventilatory function, and the alteration of some of its structures, such as those which occur in decompensated cirrhosis of the liver, for example the presence of ascites and muscle atrophy, directly influence its normal function.

METHODS

In the present study we have evaluated the ventilatory function and respiratory muscular tension by means of the calculation of volumes, flows and resistances of the airways, and also the maximum inspiratory and expiratory pressures (Pimax, Pemax).

PATIENTS

One hundred patients with liver cirrhosis and ascites without associated respiratory illness, mean age 57 +/- 15 years (range 32-80), were studied. We evaluated the respiratory function before and after the disappearance of the ascites.

RESULTS

A restrictive pattern was evident, and various parameters were altered. The most affected being that of the reserve expiratory volume. No associated bronchial obstruction was observed. Respiratory muscular tension was decreased in both the Pimax and the Pemax. With the disappearance of the ascites we found an improvement in the affected parameters, but this did not reach normality.

CONCLUSION

In liver cirrhosis associated with ascites, the most common respiratory pattern, is a decrease in ventilatory function of a restrictive type, and also a decrease in the respiratory muscular tension. These alterations improve after the resolution of the ascites.

摘要

背景

胸腔在机械通气功能中起重要作用,其某些结构的改变,如在失代偿期肝硬化中出现的结构改变,例如腹水的存在和肌肉萎缩,直接影响其正常功能。

方法

在本研究中,我们通过计算气道的容积、流量和阻力,以及最大吸气和呼气压力(Pimax、Pemax)来评估通气功能和呼吸肌张力。

患者

研究了100例无相关呼吸系统疾病的肝硬化腹水患者,平均年龄57±15岁(范围32 - 80岁)。我们在腹水消失前后评估了呼吸功能。

结果

明显呈现限制性模式,且多个参数发生改变。受影响最大的是呼气储备量参数。未观察到相关支气管阻塞。Pimax和Pemax的呼吸肌张力均降低。随着腹水的消失,我们发现受影响的参数有所改善,但未恢复正常。

结论

在伴有腹水的肝硬化中,最常见的呼吸模式是限制性通气功能降低,以及呼吸肌张力降低。腹水消退后这些改变会有所改善。

相似文献

1
[Influence of liver cirrhosis with and without ascites on ventilatory mechanics].[有无腹水的肝硬化对通气力学的影响]
Rev Esp Enferm Dig. 1995 Dec;87(12):853-7.
2
[Study of arterial blood gases in liver cirrhosis with and without ascites].[伴有和不伴有腹水的肝硬化患者动脉血气分析研究]
Rev Esp Enferm Dig. 1996 Mar;88(3):197-201.
3
Pulmonary function changes in cirrhosis of the liver.肝硬化患者的肺功能变化
Am J Gastroenterol. 1987 Apr;82(4):352-4.
4
[Age-related changes in static maximal inspiratory and expiratory pressures].[静态最大吸气和呼气压力的年龄相关变化]
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Dec;35(12):1305-11.
5
Respiratory function and liver cirrhosis.呼吸功能与肝硬化
Riv Eur Sci Med Farmacol. 1990 Apr;12(2):83-9.
6
The intraabdominal pressure in decompensated cirrhosis: relationship with ascites volume and turn-over.失代偿期肝硬化患者的腹腔内压力:与腹水量及周转率的关系
Z Gastroenterol. 1994 Jul;32(7):393-5.
7
Urinary sodium balance in patients with cirrhosis: relationship to quantitative parameters of liver function.肝硬化患者的尿钠平衡:与肝功能定量参数的关系
Hepatology. 1997 Nov;26(5):1149-55. doi: 10.1002/hep.510260510.
8
Respiratory muscular strength decrease in children with myelomeningocele.
Spine (Phila Pa 1976). 2008 Feb 1;33(3):E73-5. doi: 10.1097/BRS.0b013e3181624bc8.
9
[The effect of aging on respiratory muscle function].
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Jul;29(7):795-801.
10
[Indirect evaluation of respiratory muscle strength with the help of markers of maximal inspiratory and expiratory pressure in the mouth of healthy individuals].[借助健康个体口腔最大吸气和呼气压力指标对呼吸肌力量进行间接评估]
Pol Merkur Lekarski. 2002 Mar;12(69):178-80.

引用本文的文献

1
Dyspnea and respiratory muscle strength in end-stage liver disease.终末期肝病患者的呼吸困难与呼吸肌力量
World J Hepatol. 2013 Feb 27;5(2):56-63. doi: 10.4254/wjh.v5.i2.56.