Khan M Z, Szarek J, Marchaluk E, Macig A, Bartlewski P M
Department of Forensic Veterinary Medicine and Veterinary Medicine Administration, University of Agriculture and Technology, Olsztyn, Poland.
Biol Trace Elem Res. 1995 Aug-Sep;49(2-3):129-38. doi: 10.1007/BF02788962.
Different toxic doses of selenium and monensin preparations were administered to broiler chickens. The two substances were given by oral route, alone or concurrently, for variable periods. Erythrocyte glutathione peroxidase (GSH-Px) activity was found to be elevated after the administration of the drugs. This increase was considerably higher when selenium and monensin were administered concurrently, indicating the occurrence of strong interaction between them. Administration of selenium led to a rapid increase in the liver selenium concentration. This increase, in turn, was enhanced by concurrent application of monensin. Monensin given alone did not have any significant effect on the changes of liver selenium concentration. Further results suggest that administration of monensin increases erythrocyte GSH-Px activity, even in the absence of supplemental selenium or during increased liver selenium concentration.
将不同毒性剂量的硒制剂和莫能菌素给予肉鸡。这两种物质通过口服途径单独或同时给药，给药时间各不相同。结果发现，给药后红细胞谷胱甘肽过氧化物酶（GSH-Px）活性升高。当硒和莫能菌素同时给药时，这种升高幅度明显更高，表明它们之间发生了强烈的相互作用。给予硒会导致肝脏硒浓度迅速升高。而同时应用莫能菌素会进一步增强这种升高。单独给予莫能菌素对肝脏硒浓度的变化没有任何显著影响。进一步的结果表明，即使在没有补充硒或肝脏硒浓度升高的情况下，给予莫能菌素也会增加红细胞GSH-Px活性。
