Jonas J B, Stürmer J, Papastathopoulos K I, Meier-Gibbons F, Dichtl A
Department of Ophthalmology and Eye Hospital of the Friedrich-Alexander-University, Erlangen-Nürnberg, Germany.
Br J Ophthalmol. 1995 Dec;79(12):1102-5. doi: 10.1136/bjo.79.12.1102.
Recent reports indicate that eyes with normal pressure glaucoma have larger optic discs than eyes with primary open angle glaucoma or normal eyes. This study was performed to find whether, in normal pressure glaucoma, a large disc is associated with more optic nerve damage than a small disc.
Colour optic disc photographs of 74 patients with normal pressure glaucoma were assessed morphometrically.
Taking the study group as a whole, the optic disc size decreased significantly (p = 0.04) with increasing visual field defect. In an intraindividual bilateral comparison, the side differences in the disc area of the right minus the left eye of the same individual were not significantly correlated with the side differences in the mean visual field defect.
The results indicate that the eye with the larger optic disc, when compared with the contralateral eye with the smaller optic nerve head, showed neither a significantly more marked nor less pronounced glaucomatous optic nerve damage. It suggests that for a given patient the degree of glaucomatous optic nerve atrophy was not markedly associated with the optic disc size. The finding that patients with large visual field defects had smaller discs than patients with moderate perimetric loss may indicate that the results of previous cross sectional studies reporting on an unusually large disc size in normal pressure glaucoma may be due partially to selection.
近期报告显示，与原发性开角型青光眼患者的眼睛或正常眼睛相比，正常眼压性青光眼患者的视盘更大。本研究旨在探讨在正常眼压性青光眼中，较大的视盘是否比较小的视盘与更多的视神经损伤相关。
对74例正常眼压性青光眼患者的彩色视盘照片进行形态学测量评估。
将研究组作为一个整体来看，随着视野缺损增加，视盘大小显著减小（p = 0.04）。在个体双侧比较中，同一患者右眼与左眼视盘面积的差值与平均视野缺损的差值无显著相关性。
结果表明，与对侧视神经乳头较小的眼睛相比，视盘较大的眼睛既没有明显更严重也没有更轻微的青光眼性视神经损伤。这表明对于给定患者，青光眼性视神经萎缩的程度与视盘大小没有明显关联。视野缺损大的患者视盘比视野中度缺损的患者小，这一发现可能表明之前横断面研究报告的正常眼压性青光眼中视盘异常大的结果可能部分归因于选择偏倚。
