Torubarova N A
Biull Eksp Biol Med. 1977 Feb;83(2):211-4.
Acute hypoplasia of the hemopoiesis was induced in guinea pigs by the administration of vynbalstin in a dose of 0.1 mg per 100 g of weight, intraperitoneally, once or twice at an interval of 7 days. Myelokariocyte count, the concentration (per 10(5) of myelokariocytes) and the total amount of the fibroblast precursors was determined in the femur by the fibroblast colony method. After the administration of the cytostatic, simultaneously with the reduction of the myelokariocyte count there was noted a change in the concentration of the stromal precursors and a fall of the total precursor count per femur. It is supposed that the bone marrow reaction under hypoplasia conditions was caused by the interaction of the myeloid and stromal elements.
通过腹腔注射长春碱，以每100克体重0.1毫克的剂量，间隔7天给药一次或两次，在豚鼠中诱导急性造血功能减退。通过成纤维细胞集落法测定股骨中的骨髓有核细胞计数、（每10⁵个骨髓有核细胞）成纤维细胞前体的浓度和总量。给予细胞抑制剂后，在骨髓有核细胞计数减少的同时，还观察到基质前体浓度的变化以及每根股骨前体总数的下降。推测在发育不全条件下的骨髓反应是由髓样和基质成分的相互作用引起的。
